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Updated: Dec 28, 2025

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
To Share is Human! Advancing Evidence into Practice through a National Repository of Interoperable Clinical Decision
Edwin A Lomotan1, Ginny Meadows2, Maria Michaels3
1Division of Digital Healthcare Research, Center for Evidence and Practice Improvement, Agency for Healthcare Research and Quality, Rockville, Maryland, United States.
Sharing clinical decision support (CDS) knowledge artifacts through platforms like CDS Connect can improve efficiency and reduce duplication in healthcare systems. This national repository facilitates collaboration and innovation in developing effective CDS tools.
Area of Science:
- Health Informatics
- Clinical Decision Support Systems
- Knowledge Management in Healthcare
Background:
- Healthcare systems invest heavily in developing clinical decision support (CDS) independently, leading to resource duplication.
- Sharing knowledge about translating evidence-based practice into CDS, including workflow and technical details, could enhance efficiency and reduce redundancy.
Purpose of the Study:
- To describe how a national repository of CDS knowledge artifacts can serve as a public resource.
- To facilitate sharing and reuse of CDS artifacts among healthcare systems, researchers, and informaticists.
Main Methods:
- Evaluation of the CDS Connect platform, launched by the Agency for Healthcare Research and Quality (AHRQ) in 2016.
- Collection of user experiences from AHRQ-sponsored and community-led dissemination efforts.
- Quantitative and qualitative analysis of platform site metrics to assess early use and impact.
Main Results:
- Over 50 CDS entries contributed by federal agencies, academic institutions, and others to CDS Connect.
- Analysis indicates shared CDS resources reduce team size, tasks, and time for design, development, and deployment.
- Benefits include inspiring new projects, identifying collaborators, and improving artifacts through feedback; organizations adapt content for research and local implementation.
Conclusions:
- CDS Connect functions as a platform for active sharing of CDS development work.
- Sharing CDS knowledge artifacts can improve implementation efficiency through various pathways.
- Ongoing research aims to quantify the efficiencies gained from leveraging shared CDS artifacts.
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