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Auditory Dysfunction in Parkinson's Disease.

Zahra Jafari1,2, Bryan E Kolb1, Majid H Mohajerani1

  • 1Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB, Canada.

Movement Disorders : Official Journal of the Movement Disorder Society
|February 14, 2020
PubMed
Summary

Parkinson's disease (PD) affects hearing, causing impairments from the ear to the brain. Early detection and treatment of auditory dysfunction in PD are crucial for managing the condition.

Keywords:
Parkinson's diseaseauditory P3aauditory brainstem responsedopamineglutamatehabituationhearing losshypophoniamismatch negativitynonmotor symptoms

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Area of Science:

  • Neurology
  • Neuroscience
  • Audiology

Background:

  • Parkinson's disease (PD) is a complex neurological disorder with diverse motor and non-motor symptoms.
  • Auditory dysfunction is increasingly recognized as a significant non-motor symptom in PD.
  • Impairments span the auditory system, from peripheral hearing to central auditory processing.

Purpose of the Study:

  • To review the evidence of peripheral and central auditory impairments in Parkinson's disease.
  • To highlight the clinical relevance of auditory dysfunction in PD.
  • To propose future research directions.

Main Methods:

  • Systematic review of existing literature on auditory function in PD.
  • Analysis of electrophysiological data, including auditory evoked potentials and event-related potentials.
  • Correlation of auditory measures with disease duration and severity.

Main Results:

  • Higher incidence of hearing loss in early-onset Parkinson's disease.
  • Evidence of abnormal auditory processing in the brainstem and cortical areas.
  • Auditory P3a potentials as a sensitive indicator of PD progression.
  • Dopaminergic therapy may improve auditory responses, suggesting neurotransmitter involvement.

Conclusions:

  • Auditory dysfunction is a prevalent and often overlooked feature of Parkinson's disease.
  • Further research is needed to understand the mechanisms and clinical implications of auditory impairments in PD.
  • Integrating auditory assessments into clinical practice for PD patients is recommended.