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Molecular Identification of Phytochemical for Anticancer Treatment
Kanchana Usuwanthim1, Prapakorn Wisitpongpun1, Thitiya Luetragoon1
1Cellular and Molecular Immunology Research Unit, Faculty of Allied Health Sciences, Naresuan University, Phitsanulok 65000, Thailand.
Abstract:
Cancer commands the second highest global mortality rate and causes severe public health problems. Recent advances have been made in cancer therapy but the incidence of the disease remains high. Research on more efficient treatment methods with reduced side effects is necessary. Historically, edible plants have been used as traditional medicines for various diseases. These demonstrate the potential of natural products as sources of bioactive compounds for anticancer treatment. Anticancer properties of phytochemicals are attributed to bioactive compounds in plant extracts that suppress cancer cell proliferation and growth by inducing both cell cycle arrest and apoptosis. This review presents a summary of the molecular identification of phytochemicals with anticancer properties and details their action mechanisms and molecular targets. Moreover, the effects of the natural product on both immunomodulatory and anticancer properties are provided.
Insights
Phytochemicals from edible plants show promise as natural anticancer agents by inhibiting cancer cell growth and inducing apoptosis. This review details their molecular mechanisms and immunomodulatory effects for novel cancer therapies.
Area of Science:
- Oncology
- Pharmacology
- Natural Products Chemistry
Background:
- Cancer is a leading cause of global mortality, necessitating novel therapeutic strategies.
- Current cancer treatments face limitations, driving research into more effective and safer alternatives.
- Edible plants have a history of medicinal use, suggesting potential for anticancer compounds.
Purpose of the Study:
- To review the molecular identification of phytochemicals with anticancer properties.
- To detail the mechanisms of action and molecular targets of these plant-derived compounds.
- To summarize the immunomodulatory and anticancer effects of natural products.
Main Methods:
- Literature review focusing on molecular identification of phytochemicals.
- Analysis of studies detailing anticancer mechanisms (cell cycle arrest, apoptosis).
- Examination of research on immunomodulatory effects of natural products.
Main Results:
- Phytochemicals exhibit anticancer activity by suppressing cancer cell proliferation.
- Mechanisms include induction of cell cycle arrest and apoptosis.
- Natural products also demonstrate immunomodulatory properties relevant to cancer therapy.
Conclusions:
- Phytochemicals from edible plants represent a promising source for developing new anticancer drugs.
- Understanding their molecular targets and mechanisms is crucial for drug development.
- The dual anticancer and immunomodulatory effects warrant further investigation for comprehensive cancer treatment.
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