Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

3D Reactive Oxygen Species Dosimetry in Pleural Photodynamic Therapy: Integration of Macroscopic Kinetic Modeling and Deformable Registration.

Antioxidants (Basel, Switzerland)·2026
Same author

Dosimetric Performance Analysis of Pediatric Based Halcyonâ„¢ Volumetric Arc Therapy-Based Lung-Sparing Total Body Irradiation.

Technology in cancer research & treatment·2026
Same author

Comparison of multispectral singlet oxygen luminescence dosimetry and singlet oxygen explicit dosimetry in artificial phantom.

Journal of biomedical optics·2025
Same author

First multi-institutional systematic comparison of the neutron ambient dose equivalent produced by proton therapy systems.

Physics in medicine and biology·2025
Same author

Real World Radiographic Response Rates and Preoperative Attrition in Patients With Non-Small Cell Lung Cancer (NSCLC) Treated With Neoadjuvant Chemoimmunotherapy.

American journal of clinical oncology·2025
Same author

Primary Tumor Failure After Definitive Chemoradiation in Locally Advanced Non-Small Cell Lung Cancer: A Brief Report on the Implications for NRG LU-008.

International journal of radiation oncology, biology, physics·2025

Related Experiment Video

Updated: Dec 28, 2025

Near Infrared Photoimmunotherapy for Mouse Models of Pleural Dissemination
05:39

Near Infrared Photoimmunotherapy for Mouse Models of Pleural Dissemination

Published on: February 9, 2021

3.6K

Infrared navigation system for light dosimetry during pleural photodynamic therapy.

Michele M Kim1, Timothy C Zhu1, Yi Hong Ong1,2

  • 1Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA, United States of America.

Physics in Medicine and Biology
|February 14, 2020
PubMed
Summary

Accurate light dose delivery in pleural photodynamic therapy (PDT) for mesothelioma is crucial. This study introduces an optical navigation system to improve light dose calculation and uniformity, achieving within 15% accuracy compared to measurements.

More Related Videos

Selective Cell Elimination from Mixed 3D Culture Using a Near Infrared Photoimmunotherapy Technique
05:18

Selective Cell Elimination from Mixed 3D Culture Using a Near Infrared Photoimmunotherapy Technique

Published on: March 14, 2016

8.2K
An In-House-Built and Light-Emitting-Diode-Based Photodynamic Therapy Device for Enhancing Verteporfin Cytotoxicity in a 2D Cell Culture Model
11:04

An In-House-Built and Light-Emitting-Diode-Based Photodynamic Therapy Device for Enhancing Verteporfin Cytotoxicity in a 2D Cell Culture Model

Published on: January 13, 2023

3.5K

Related Experiment Videos

Last Updated: Dec 28, 2025

Near Infrared Photoimmunotherapy for Mouse Models of Pleural Dissemination
05:39

Near Infrared Photoimmunotherapy for Mouse Models of Pleural Dissemination

Published on: February 9, 2021

3.6K
Selective Cell Elimination from Mixed 3D Culture Using a Near Infrared Photoimmunotherapy Technique
05:18

Selective Cell Elimination from Mixed 3D Culture Using a Near Infrared Photoimmunotherapy Technique

Published on: March 14, 2016

8.2K
An In-House-Built and Light-Emitting-Diode-Based Photodynamic Therapy Device for Enhancing Verteporfin Cytotoxicity in a 2D Cell Culture Model
11:04

An In-House-Built and Light-Emitting-Diode-Based Photodynamic Therapy Device for Enhancing Verteporfin Cytotoxicity in a 2D Cell Culture Model

Published on: January 13, 2023

3.5K

Area of Science:

  • Oncology
  • Medical Physics
  • Surgical Technology

Background:

  • Pleural photodynamic therapy (PDT) treats microscopic disease in malignant pleural mesothelioma.
  • Accurate light dose delivery is essential for PDT efficacy.
  • Current methods use discrete detectors, potentially missing areas between locations.

Purpose of the Study:

  • To develop and validate an improved method for calculating and monitoring light dose during intraoperative pleural PDT.
  • To enhance light fluence uniformity and accuracy within the pleural cavity.
  • To assess the real-time applicability of the developed system in surgical settings.

Main Methods:

  • An optical infrared (IR) navigation system tracked a modified treatment wand with passive markers.
  • Light dose was calculated using a dual correction method with a constant scattered light dose.
  • Light fluence uniformity was quantified in 3D and compared to measurements from eight isotropic detectors across seven patient cases.

Main Results:

  • The developed method achieved a difference within 15% between calculated and measured light fluence values.
  • Light fluence uniformity showed a standard deviation of 10% across the pleural cavity.
  • The system accurately determined light dose delivery between detector locations.

Conclusions:

  • The optical navigation system and dual correction method improve the accuracy and uniformity of light dose delivery in pleural PDT.
  • This approach enhances treatment precision for malignant pleural mesothelioma.
  • Real-time implementation in surgery can optimize PDT outcomes.