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Microbiome of the first stool after birth and infantile colic

Katja Korpela1, Marjo Renko2,3, Niko Paalanne4,2

  • 1PEDEGO Research Unit and Medical Research Centre Oulu, University of Oulu, Oulu, Finland. katja.korpela@oulu.fi.

Pediatric Research
|February 14, 2020
PubMed

Insights

The first stool microbiome composition in newborns is linked to infantile colic. Lower levels of Lactobacillus and Firmicutes in the first stool may predict colic development, suggesting early gut health impacts infant well-being.

Area of Science:

  • Microbiome research
  • Pediatric health
  • Gut-brain axis

Background:

  • The first stool microbiome is diverse but its clinical significance is unknown.
  • Infantile colic has been previously linked to gut microbiome composition.

Purpose of the Study:

  • To investigate the association between the first stool microbiome and the development of infantile colic.
  • To determine if early microbiome markers can predict infantile colic.

Main Methods:

  • Prospective, population-based cohort study of 212 newborns.
  • Next-generation sequencing of the bacterial 16S rRNA gene was used to analyze the first stool microbiome.
  • Random forest algorithm was employed to classify newborns based on microbiome data.

Main Results:

  • Newborns who developed infantile colic (n=19) showed a lower relative abundance of Lactobacillus and Firmicutes in their first stool compared to healthy infants (n=139).
  • The microbiome data, analyzed by a random forest algorithm, could classify newborns with subsequent colic with an area under the curve of 0.66 (P < 0.001).

Conclusions:

  • The microbiome of the first-pass meconium is associated with subsequent infantile colic.
  • These findings suggest that the pathogenesis of infantile colic is closely related to the intestinal microbiome at birth.
Abstract

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