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Respiratory viruses in mechanically ventilated patients: a pilot study
Raquel Nazareth1,2, Maria-Jesus Chasqueira3, Maria-Lúcia Rodrigues3
1Hospital Beatriz Ângelo, Avenida Carlos Teixeira, 3, 2674-514, Loures, Portugal. raquelnazareth@gmail.com.
Common respiratory viruses were found in the lower airways of patients, even those without infection. This finding impacts how respiratory illness is diagnosed and treated in clinical settings.
Area of Science:
- Microbiology
- Virology
- Pulmonology
Background:
- The respiratory virome is a key component of the human microbiome.
- Understanding viral presence in the lower airways aids in managing acute lower respiratory infections.
Purpose of the Study:
- To investigate the prevalence of respiratory viruses in the lower respiratory tract of mechanically ventilated patients.
- To compare viral detection in patients with (WRI) and without (WORI) acute lower respiratory infection.
Main Methods:
- Mini-bronchoalveolar lavage samples were collected from 44 patients (20 WORI, 24 WRI).
- Real-time PCR was used to detect 15 common respiratory viruses.
- Patients were hospitalized for acute respiratory failure in Lisbon-area ICUs.
Main Results:
- Respiratory viruses were detected in 30% of WORI patients and 50% of WRI patients.
- Influenza AH3, human rhinovirus, and respiratory syncytial virus were common in both groups.
- Simultaneous detection of two viruses occurred in some samples from both groups.
Conclusions:
- Common respiratory viruses can be present in the lower respiratory tract without causing symptomatic infection.
- These findings have significant implications for interpreting diagnostic results in clinical practice.
- Careful sample collection is crucial for accurate assessment of lower airway infections.
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