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Updated: Dec 28, 2025

Functional and Physiological Methods of Evaluating Median Nerve Regeneration in the Rat
Published on: April 18, 2020
Median Nerve Variation: A Complete Spin before Terminal Branching.
Amgad S Hanna1, Zhikui Wei2, Barbara A Hanna3
1Department of Neurological Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States.
A rare median nerve anatomical variant was found in the wrist, with the nerve deep to the flexor digitorum superficialis and twisting 360 degrees. This discovery highlights the need to recognize such median nerve variations during surgery.
Area of Science:
- Anatomy
- Clinical Neuroscience
- Surgical Anatomy
Background:
- The median nerve is crucial for forearm and hand function.
- Understanding median nerve anatomy is vital for diagnosing and treating neurological conditions.
- Anatomical variations can complicate surgical procedures and diagnostic interpretations.
Observation:
- A unique median nerve anatomical variant was identified during a cadaveric dissection in the distal forearm and wrist.
- The median nerve was observed to be deep to the flexor digitorum superficialis (FDS) within the carpal tunnel.
- The nerve exhibited a rare 360-degree rotation before re-emerging, with its recurrent motor branch shifting position.
Findings:
- This variant does not conform to existing classifications of median nerve anomalies (Lanz's groups).
- A novel fifth group for median nerve course variations is proposed.
- The recurrent motor branch demonstrated an unusual medial to lateral trajectory on the nerve's deep surface.
Implications:
- Recognizing this median nerve variant is essential for surgeons operating in the forearm and wrist.
- Such anatomical variations can impact the diagnosis and treatment of conditions like carpal tunnel syndrome.
- This finding contributes to a more comprehensive understanding of peripheral nerve anatomy and its clinical relevance.
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