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Development of a user-friendly training software for pharmacokinetic concepts and models

Seunghoon Han^1,2, Byounghee Lim^1,2, Hyemi Lee^1,2

¹PIPET (Pharmacometrics Institute for Practical Education and Training), College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.

Translational and Clinical Pharmacology

|February 15, 2020

Summary

This study developed flexible pharmacokinetic (PK) simulation software for education. The user-friendly tool enables rapid simulation of drug concentration time courses, enhancing learning for various audiences.

Area of Science:

Pharmacology
Computational Biology
Educational Technology

Background:

Commercially available pharmacokinetic software often lacks flexibility and user convenience.
Effective pharmacokinetic education requires adaptable tools for simulating diverse scenarios.

Purpose of the Study:

To develop a flexible and convenient simulation software to enhance pharmacokinetics education.
To create a tool that allows users to tailor simulations to specific learning objectives.

Main Methods:

Developed source code using R based on general formulas for drug concentration time courses.
Implemented a 1-compartment model using differential equations and incorporated population pharmacokinetics concepts.
Created a web-based simulator and a standalone Java application, utilizing a JAVA/R Interface for seamless integration.

Main Results:

The developed software provides an intuitive interface for inputting parameters, dosing regimens, and population pharmacokinetics options.
Simulation results, including drug concentration time courses, are generated rapidly (within 1 minute), even with complex population PK models.
The software facilitates quick learning of various pharmacokinetic scenarios.

Conclusions:

The developed simulation software offers a flexible and convenient alternative to existing commercial options for pharmacokinetics education.
This tool is suitable for a wide range of users, from undergraduates to experts, and has potential as an open educational resource.
The software's efficiency and adaptability make it a valuable asset for teaching and learning pharmacokinetics.

Keywords:

Pharmacokinetics Simulation Training Software

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