Design of stroke imaging package study of intracranial atherosclerosis: a multicenter, prospective, cohort study
Qianqian Lin1, Xiaoyun Liu2, Beilei Chen3
1Department of Neurology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China.
Insights
The Stroke Imaging Package Study of Intracranial Atherosclerosis (SIPS-ICAS) uses high-resolution MRI to investigate stroke mechanisms and treatment effects in patients with intracranial atherosclerosis. This study aims to identify imaging markers for better risk prediction.
Area of Science:
- Neurology
- Radiology
- Cardiovascular Research
Background:
- Intracranial atherosclerosis (ICAS) is a significant global cause of stroke.
- The pathophysiology of ICAS requires further elucidation.
- High-resolution magnetic resonance imaging (HR-MRI) offers in vivo visualization of intracranial vessel wall lesions.
Purpose of the Study:
- To explore stroke mechanisms in symptomatic ICAS.
- To investigate dynamic changes in ICAS under aggressive medical treatment.
- To associate imaging findings with clinical events using HR-MRI and conventional sequences.
Main Methods:
- Multicenter, prospective cohort study design.
- Recruitment of first-ever acute ischemic stroke patients with significant intracranial large artery stenosis (>50% or occlusion).
- Baseline stroke imaging package including HR-MRI, followed by aggressive medical treatment, and follow-up imaging at 6 months.
Main Results:
- Enrollment commenced in November 2018.
- As of September 2019, 96 patients have been enrolled in the study.
Conclusions:
- The SIPS-ICAS study is expected to yield insights into ICAS pathophysiology.
- Identification of specific imaging markers for risk stratification and prognosis prediction is anticipated.
- The study will assess the feasibility and validity of the novel stroke imaging package, including HR-MRI, for potential clinical use.
Background:
Intracranial atherosclerosis (ICAS) is a major cause of stroke worldwide. However, much remains unknown regarding its underlying pathophysiology. High-resolution magnetic resonance imaging (HR-MRI) can clearly display intracranial vessel wall lesions in vivo. The aim of stroke imaging package study of ICAS (SIPS-ICAS) study is to explore the stroke mechanisms of symptomatic ICAS, the dynamic changes under aggressive medical treatment and their associations with clinical events using conventional MRI sequences plus HR-MRI.
Methods:
This is a multicenter, prospective, cohort study recruiting first-ever acute ischemic stroke patients attributed to intracranial large artery stenosis (>50% or occlusion). Subjects undergo a pre-designed stroke imaging packages at baseline and are recommended to receive aggressive medical treatments. Participants will be followed up for functional outcome, stroke recurrence, and death events at 3, 6 and 12 months and retake HR-MRI imaging at 6 months.
Results:
Enrollment began in November 2018 and 96 patients have been enrolled as of September 2019.
Conclusions:
The SIPS-ICAS study will provide insights into the pathophysiology of ICAS and identify specific imaging markers for risk stratification and prognosis prediction. At the same time, the feasibility and validity of the new stroke imaging package including HR-MRI will be assessed, which is promising for clinical routine use.
More Related Videos
06:45Author Spotlight: Integrated Photoacoustic, Ultrasound, and Angiographic Tomography (PAUSAT) for NonInvasive Whole-Brain Imaging of Ischemic Stroke
Published on: June 2, 2023
13:07Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression
Published on: January 15, 2022
Related Concept Videos
01:21Imaging Studies for Cardiovascular System IV: CMRI
01:19Imaging Studies VII: Vascular Imaging
01:28Imaging Studies for Cardiovascular System V: CT
01:25Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT
01:20Imaging Studies for Cardiovascular System III: X-Ray
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...