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Assessment of the Antithrombogenicity of a Poly-2-Methoxyethylacrylate-Coated Central Venous Port-Catheter System

Shuji Kariya1, Miyuki Nakatani2, Yasuyuki Ono2

  • 1Department of Radiology, Kansai Medical University, 2-5-1 Shinmachi, Hirakata, Osaka, 5731010, Japan. kariyas@hirakata.kmu.ac.jp.

Cardiovascular and Interventional Radiology
|February 15, 2020
PubMed
Abstract

Insights

Poly-2-methoxyethylacrylate (PMEA) coating significantly reduced thrombus formation in port-catheter systems. This antithrombotic coating facilitates easier flushing of residual thrombi and protein, improving system performance.

Area of Science:

  • Biomaterials Science
  • Medical Device Engineering
  • Thrombosis Research

Background:

  • Central venous port-catheter systems are prone to thrombotic occlusion, a complication that can impair device function and lead to adverse events.
  • Preventing thrombus formation on internal surfaces is crucial for maintaining the patency and longevity of these medical devices.

Purpose of the Study:

  • To investigate the antithrombogenic efficacy of poly-2-methoxyethylacrylate (PMEA) coating on the internal surfaces of port-catheter systems.
  • To assess the PMEA coating's ability to prevent thrombotic occlusion and facilitate thrombus removal.

Main Methods:

  • PMEA coating was applied to the internal surfaces of port-catheter systems (chamber, catheter, connecting stem).
  • Coated and uncoated systems were filled with fresh human blood for 1 or 3 hours.
  • Residual thrombus mass and protein levels were quantified after saline flushing and compared between coated and uncoated systems.

Main Results:

  • PMEA-coated systems showed complete expulsion of visually recognizable thrombi with saline flushing, leaving no adhesions.
  • Uncoated systems exhibited adherent thrombi and incomplete expulsion upon flushing.
  • Significantly lower mean residual thrombus mass (20.5 ± 6.2 mg vs. 230.3 ± 92.5 mg; p < 0.01) and protein levels were observed in PMEA-coated systems compared to uncoated systems.

Conclusions:

  • PMEA coating effectively reduces thrombus accumulation within central venous port-catheter systems.
  • The antithrombotic properties of PMEA facilitate easier flushing of thrombi and proteins, enhancing system performance.
  • PMEA-coated port-catheter systems demonstrate a significant antithrombotic advantage over uncoated systems.
Keywords:
AntithrombogenicityCoatingComplicationPoly-2-methoxyethylacrylatePortThrombosis

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