Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Limbic encephalitis associated with malignant thymoma.

J P McArdle1, K S Millingen

  • 1Department of Anatomical Pathology, Royal Hobart Hospital.

Pathology
|July 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Richter's hernia of the splenic flexure: computed tomography appearances.

Australasian radiology·1994
Same author

Hyperparathyroidism with chronic parathyroiditis in a multiple endocrine neoplasia patient.

The Australian and New Zealand journal of surgery·1993
Same author

Multiple endocrine neoplasm, type 1. Gastrinomas, pancreatic neoplasms, microcarcinoids, the Zollinger-Ellison syndrome, lymph nodes, and hepatic metastases.

Archives of surgery (Chicago, Ill. : 1960)·1993
Same author

Cause of death in multiple endocrine neoplasia type 1.

Archives of surgery (Chicago, Ill. : 1960)·1993
Same author

Three-dimensional assessment of surgical excision margins in skin tumor resection biopsies.

Pathology·1990
Same author

Primary rhabdomyosarcoma of the adult liver.

The American journal of surgical pathology·1989
Same journal

Impact of the 2025 Endocrine Society clinical practice guideline on the diagnosis and management of primary aldosteronism for the clinical laboratory.

Pathology·2026
Same journal

Cribriform intraductal carcinoma of the prostate may have a greater prognostic impact even than Gleason grade 5 conventional prostatic adenocarcinoma.

Pathology·2026
Same journal

Bordetella pertussis: emerging epidemiology, diagnosis and management.

Pathology·2026
Same journal

Development and validation of a real-time polymerase chain reaction for the detection of Haycocknema perplexum.

Pathology·2026
Same journal

Recent advances in the understanding of TP53 in haematological malignancies.

Pathology·2026
Same journal

Concurrent renal amyloid light chain amyloidosis, light chain crystalline podocytopathy and light chain proximal tubulopathy: a case report.

Pathology·2026
See all related articles

A rare case of limbic encephalitis linked to recurrent malignant thymoma was observed. Autopsy revealed specific brain changes, highlighting a fatal neurological-cancer connection.

Area of Science:

  • Neurology
  • Oncology
  • Pathology

Background:

  • Limbic encephalitis is a rare autoimmune disorder affecting the medial temporal lobes.
  • Malignant thymoma is a primary tumor of the thymus gland.
  • Paraneoplastic syndromes can manifest as neurological disorders associated with cancer.

Observation:

  • A 41-year-old male with recurrent malignant thymoma presented with acute confusion, memory loss, hallucinations, and behavioral changes.
  • The patient exhibited autonomic dysfunction, including tachycardia and profuse sweating.
  • Initial investigations failed to identify the cause of the rapid clinical deterioration.

Findings:

  • Autopsy revealed bilateral extensive neuronal loss and reactive gliosis.
  • The neuropathological changes were confined to the medial temporal cortex and Ammon's horn.

Related Experiment Videos

  • These findings confirmed limbic encephalitis as the cause of death.

    • Implications:

    • This case underscores the potential for thymoma to trigger limbic encephalitis, a severe neurological paraneoplastic syndrome.
    • Early recognition and treatment of paraneoplastic neurological disorders are crucial for improving patient outcomes.
    • Further research is needed to elucidate the specific mechanisms linking thymoma and limbic encephalitis.