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Updated: Dec 28, 2025

Development of Compendium for Esophageal Squamous Cell Carcinoma
Published on: April 12, 2024
Mass Spectrometry for Biomarkers Discovery in Esophageal Squamous Cell Carcinoma
Farhadul Islam1,2, Vinod Gopalan1, Alfred K Lam3
1Cancer Molecular Pathology of School of Medicine, Griffith University, Gold Coast, Queensland, Australia.
Abstract:
Mass spectrometry-based proteomics analysis could categorize proteins and study their interactions in large scale in human cancers. By this method, many proteins are upregulated or downregulated in esophageal squamous cell carcinoma (ESCC) when compared to nonneoplastic esophageal mucosae. The method can also be used to identify novel, effective biomarkers for early diagnosis or predict prognosis of patients with ESCC. These changes are associated with different clinical and pathological parameters. Different biological matrices such as pathological tissue, body fluids, and cancer cell lines-based proteomics have widely been used. Herein, we described cell line-based label-free shotgun proteomics (in-solution tryptic digestion) to identify the protein biomarkers differently expressed in ESCC.
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