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Invited Review: Epigenetics in neurodevelopment.

R D Salinas1, D R Connolly2, H Song2,3,4,5,6,7

  • 1Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA, USA.

Neuropathology and Applied Neurobiology
|February 15, 2020
PubMed
Summary
This summary is machine-generated.

Epigenetic mechanisms, including DNA methylation and RNA modifications, are crucial for neural development and diseases. These processes interact dynamically to control cell fate, with multi-omic approaches offering future insights.

Keywords:
DNA methylationchromatin remodellingdevelopmental disorderepitranscriptomicsneurogenesis

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Area of Science:

  • Neuroscience
  • Epigenetics
  • Developmental Biology

Background:

  • Neural development relies on precise gene expression control for cell fate decisions.
  • Epigenetics, heritable gene expression changes beyond DNA sequence, profoundly influences this process.
  • Emerging technologies enable detailed analysis of epigenetic and gene regulation features.

Purpose of the Study:

  • To provide an overview of key epigenetic regulatory modes in neurodevelopment and disease.
  • To highlight the interactive nature of these epigenetic mechanisms.
  • To discuss future directions utilizing multi-omic and advanced model systems.

Main Methods:

  • Review of established and novel epigenetic regulatory mechanisms.
  • Discussion of DNA methylation, histone modifications, noncoding RNAs, and epitranscriptomics.
  • Consideration of multi-omic strategies and human neurodevelopmental models (iPSC, organoids).

Main Results:

  • Epigenetic regulation, encompassing DNA methylation, histone modifications, noncoding RNAs, and epitranscriptomics, is central to neurodevelopment.
  • These epigenetic modes do not function independently but interact dynamically.
  • These interactions coordinate complex neurodevelopmental processes.

Conclusions:

  • Understanding the interplay of epigenetic mechanisms is vital for comprehending neurodevelopment and associated diseases.
  • Multi-omic approaches and advanced human models are essential for future research.
  • Investigating these interactions will illuminate human-specific neurodevelopmental features and diseases.