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Related Experiment Videos

Trichloroethylene: a cardiac teratogen in developing chick embryos.

C P Loeber1, M J Hendrix, S Diez De Pinos

  • 1Department of Pediatrics, University of Arizona, Tucson 85724.

Pediatric Research
|December 1, 1988
PubMed
Summary

Trichloroethylene (TCE), a common drinking water contaminant, was found to cause heart defects in developing avian embryos. This study confirms TCE as a cardiac teratogen, highlighting risks to early embryogenesis.

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Area of Science:

  • Developmental toxicology
  • Environmental health
  • Cardiovascular embryology

Background:

  • Trichloroethylene (TCE) is a widespread environmental contaminant found in drinking water.
  • Previous research has explored TCE's general teratogenic potential, but its specific impact on heart development remained uninvestigated.

Purpose of the Study:

  • To investigate whether trichloroethylene (TCE) acts as a cardiac teratogen during early embryogenesis.
  • To assess the effects of TCE exposure on heart development in a validated avian model.

Main Methods:

  • Fertile chicken eggs were exposed to varying concentrations of TCE (5-25 microM) at different embryonic stages (6, 12, 18, 23).
  • Control groups received saline or mineral oil injections.
  • A total of 1055 embryonic hearts were examined at stages 29, 34, and 44 using gross examination and microdissection.

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  • The study employed a double-blinded methodology.

    • Main Results:

    • Trichloroethylene (TCE) exposure resulted in a significantly higher incidence of cardiac malformations (7.3%) compared to saline (2.3%) and mineral oil (1.5%) controls.
    • Specific cardiac defects observed included septal defects, cor biloculare, conotruncal abnormalities, atrioventricular canal defects, and abnormal cardiac muscle.
    • No significant difference in malformation rates was observed between saline and mineral oil controls.

    Conclusions:

    • The findings demonstrate that trichloroethylene (TCE) is a cardiac teratogen in the studied avian model.
    • TCE exposure during early embryogenesis can lead to a range of structural heart defects.
    • This research underscores the potential risks of TCE contamination in drinking water to embryonic heart development.