Indole-N-Carboxylic Acids and Indole-N-Carboxamides in Organic Synthesis
Linwei Zeng1, Yuxin Lin1, Sunliang Cui1
1Institute of Drug Discovery and Design, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.
Abstract:
Indoles are ubiquitous structures that are found in natural products and biologically active molecules. The synthesis of indoles and indole-involved synthetic methodologies in organic chemistry have been receiving considerable attention. Indole-N-carboxylic acids and derived indole-N-carboxamides are intriguing compounds, which have been widely used in organic synthesis, especially in multicomponent reactions and C-H functionalization of indoles. This Minireview summarizes the advances of reactions involving indole-N-carboxylic acids and indole-N-carboxamides in organic chemistry, and discusses the synthetic potential and perspective of this field.
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