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High Throughput Co-culture Assays for the Investigation of Microbial Interactions
Published on: October 15, 2019
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Emergence of coagulase-negative staphylococci.
Karsten Becker1,2, Anna Both3, Samira Weißelberg3
1Friedrich Loeffler-Institute of Medical Microbiology, University Medicine Greifswald, Greifswald, Germany.
Expert Review of Anti-Infective Therapy
|February 15, 2020
Summary
Coagulase-negative staphylococci (CoNS) are emerging pathogens, especially in immunocompromised patients and with implanted devices. Developing novel strategies is crucial to combat therapy-refractory CoNS infections.
Area of Science:
- Microbiology
- Infectious Diseases
- Medical Science
Background:
- Coagulase-negative staphylococci (CoNS) are increasingly significant pathogens, particularly in vulnerable populations and with medical implants.
- Unlike Staphylococcus aureus, CoNS infections are often chronic and difficult to treat with antibiotics, frequently necessitating device removal.
Purpose of the Study:
- To review the emergence and pathogenic potential of CoNS species.
- To discuss CoNS biofilm formation, evasion strategies, and medical significance.
- To explore current and novel therapeutic approaches for CoNS infections.
Main Methods:
- Literature review focusing on CoNS emergence, pathogenicity, and treatment strategies.
- Analysis of CoNS biofilm formation and host-pathogen interactions.
- Discussion of medical and socio-economic impact of CoNS infections.
Main Results:
- CoNS form therapy-refractory biofilms on biotic and abiotic surfaces.
- CoNS possess evasion strategies against host immune responses and antibiotic treatments.
- Increasing use of foreign materials and immunocompromised populations contribute to CoNS emergence.
Conclusions:
- CoNS infections pose significant morbidity and socio-economic burdens.
- Rising antimicrobial resistance in CoNS strains limits treatment options.
- Further research is needed for innovative prevention and treatment strategies, including anti-colonization materials.
