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Umbilical cord as an analytical matrix - A technical note
Hayley R Price1, Camron Chehroudi2, Stuart J Knight1
1Faculty of Pharmaceutical Sciences, The University of British Columbia, 2405 Wesbrook Mall, Vancouver, BC, V6T 1Z3, Canada.
Placenta
|February 15, 2020
Summary
The umbilical cord (UC) is a valuable biological matrix for detecting drugs and chemicals. This guide details its advantages and challenges for analytical use.
Area of Science:
- Toxicology
- Analytical Chemistry
- Biomedical Science
Background:
- The umbilical cord (UC) serves as a crucial link between the fetus and placenta, receiving systemic endo- and xenobiotics.
- Extensive experience exists in utilizing UC as an analytical matrix for detecting and quantifying various compounds.
- Understanding UC's properties is vital for its application in biomedical and toxicological analyses.
Purpose of the Study:
- To describe the advantages of using umbilical cord (UC) as an analytical matrix.
- To outline the challenges associated with employing UC in analytical methodologies.
- To provide guidance for effective utilization of UC tissue in laboratory settings.
Main Methods:
- Evaluation of UC as an analytical matrix for detecting drugs, chemicals, and endogenous compounds.
- Assessment of UC's suitability for Enzyme-Linked Immunosorbent Assay (ELISA) platforms.
- Analysis of UC's compatibility with Liquid Chromatography-Mass Spectrometry (LC/MS) detection technologies.
Main Results:
- Umbilical cord (UC) offers advantages such as large availability, ease of collection, minimal sample requirement, and rapid accessibility.
- Challenges include understanding clinical relationships, difficulties in tissue processing, and potential matrix effects on analytes and detection methods.
- Successful application of UC in ELISA and LC/MS requires careful consideration of these factors.
Conclusions:
- The umbilical cord (UC) is a promising analytical matrix with significant advantages for drug and chemical detection.
- Addressing the inherent challenges is key to optimizing UC's use in toxicological and clinical research.
- This technical note offers practical guidance for researchers working with UC as an analytical matrix.
Keywords:
Drug screeningELISALaboratory methodsMass spectrometryMaternal-fetal outcomesPharmacokineticsToxicologyMore Related Videos
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