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Updated: Dec 28, 2025

Ligand-Mediated Nucleation and Growth of Palladium Metal Nanoparticles
Published on: June 25, 2018
A solid support generator of the Auger electron emitter rhodium-103m from [103Pd]palladium
Andreas I Jensen1, Fedor Zhuravlev1, Gregory Severin2
1Center for Nuclear Technologies (DTU Nutech), Technical University of Denmark (DTU), Frederiksborgvej 399, 4000, Roskilde, Denmark.
Rhodium-103m, an Auger electron emitter, was purified for targeted cancer therapy. This method utilizes palladium-103 decay and a novel chelation technique for radiochemical purity.
Area of Science:
- Nuclear medicine
- Radiochemistry
- Oncology
Background:
- Auger electron therapy offers precise targeting of microscopic tumors.
- Rhodium-103m (103mRh) is a potent Auger electron emitter derived from Palladium-103 (103Pd).
Purpose of the Study:
- To develop a method for obtaining radiochemically pure 103mRh for potential therapeutic applications.
- To investigate the purification mechanism of 103mRh from 103Pd.
Main Methods:
- 103Pd was chelated within a lipophilic derivative of the 16aneS4 macrocycle.
- The complex was immobilized on a C18 cartridge.
- Radiochemically pure 103mRh was eluted using dilute hydrochloric acid.
Main Results:
- A method was established to isolate radiochemically pure 103mRh.
- The purification process likely involves the Szilard-Chalmers effect and transient ionization.
Conclusions:
- This study presents a viable method for producing 103mRh for Auger electron therapy.
- The findings contribute to the development of targeted radionuclide therapies.
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