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Updated: Dec 28, 2025

Ligand-Mediated Nucleation and Growth of Palladium Metal Nanoparticles
Published on: June 25, 2018
A solid support generator of the Auger electron emitter rhodium-103m from [103Pd]palladium
Andreas I Jensen1, Fedor Zhuravlev1, Gregory Severin2
1Center for Nuclear Technologies (DTU Nutech), Technical University of Denmark (DTU), Frederiksborgvej 399, 4000, Roskilde, Denmark.
Abstract:
Auger electron therapy is an attractive modality for targeting microscopic tumors. Rhodium-103 m (103mRh, T½ = 56.1 min) is a promising Auger electron emitter that can be obtained as the decay product of palladium-103 (103Pd, T½ = 16.99 days). 103Pd was chelated in a lipophilic derivative of the 16aneS4 macrocycle and the complex was trapped on a C18 cartridge. Elution with dilute hydrochloric acid gave radiochemically pure 103mRh. We hypothesize this to be through a combination of the Szilard-Chalmers effect and transient ionization.
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