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Zika virus NS5 localizes at centrosomes during cell division

Aditi S Kesari1, Veronica J Heintz1, Shishir Poudyal2

  • 1Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN, 47907, USA; Department of Molecular Pharmacology, Purdue University, West Lafayette, IN, 47907, USA; Purdue Institute of Inflammation, Immunology and Infectious Disease, Purdue University, West Lafayette, IN, 47907, USA.

Virology
|February 15, 2020
PubMed
Summary

Zika virus nonstructural protein 5 (NS5) moves from the nucleus to centrosomes during mitosis. This viral protein interacts with centrosomal components, potentially impacting cell division.

Keywords:
CentrosomeFlavivirusNonstructural protein NS5RNA-Dependent RNA polymeraseZika virus

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