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Recent advances in high-sensitivity detection methods for paper-based lateral-flow assay.

Van-Thuan Nguyen1, Seungri Song1, Seungkyung Park2

  • 1Department of Mechanical Engineering, Yonsei University, 50 Yonsei-ro, Seodaemoon-gu, Seoul, 03722, Republic of Korea.

Biosensors & Bioelectronics
|February 15, 2020
PubMed
Summary

High-sensitivity lateral-flow assays (LFAs) improve medical diagnostics by using advanced particle technologies for more accurate detection of critical biomarkers. These enhanced LFAs offer greater sensitivity and reliability beyond traditional visual methods.

Keywords:
Electro-chemicalHigh-sensitivityLateral-flow assayMagneticOpticalPhotoacoustic

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Area of Science:

  • Biomedical Engineering
  • Analytical Chemistry
  • Point-of-Care Diagnostics

Background:

  • Paper-based lateral-flow assays (LFAs) are widely used in diagnostics and environmental monitoring.
  • Conventional LFAs rely on visual colorimetric detection, limiting sensitivity and quantitative accuracy for low-concentration analytes.
  • There is a critical need for more sensitive detection methods for early disease diagnosis and precise environmental monitoring.

Purpose of the Study:

  • To provide an objective overview of recent advancements in high-sensitivity lateral-flow assay detection technologies.
  • To discuss technologies that exploit the physical and chemical responses of transducing particles for enhanced LFA performance.
  • To analyze the features, biomedical applications, future prospects, and challenges of these advanced LFA detection methods.

Main Methods:

  • Review of emerging technologies for high-sensitivity detection in lateral-flow assays.
  • Focus on methods utilizing transducing particles and their physical/chemical responses.
  • Analysis of commercialization efforts and technological progress in the field.

Main Results:

  • Diverse high-sensitivity LFA detection technologies have been developed, moving beyond naked-eye visual detection.
  • These technologies leverage the unique properties of transducing particles to achieve superior sensitivity and quantitative measurements.
  • Significant progress has been made in enhancing the detection limits and reliability of LFAs for critical biomarkers.

Conclusions:

  • High-sensitivity LFA detection technologies are crucial for advancing medical diagnostics and environmental monitoring.
  • Exploiting transducing particles offers a promising pathway to overcome the limitations of conventional LFAs.
  • Further development and commercialization are essential to realize the full potential of these advanced diagnostic tools.