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Uncal apex position varies with normal aging.

Jordan Poppenk1,2,3,

  • 1Department of Psychology, Queen's University, Kingston, Ontario, Canada.

Hippocampus
|February 15, 2020
PubMed
Summary
This summary is machine-generated.

The uncal apex shifts anteriorly with age, affecting hippocampal volume measurements. This age-related change impacts anterior and posterior hippocampus segmentation, suggesting caution in aging research.

Keywords:
aginganterior hippocampuslong axisposterior hippocampusuncal apex

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Area of Science:

  • Neuroimaging
  • Human Anatomy
  • Aging Research

Background:

  • The uncal apex is a key landmark for segmenting the hippocampus into anterior and posterior regions.
  • Its reliability in the context of age-related hippocampal changes remains unestablished.
  • Potential impacts on anterior hippocampus (aHPC) and posterior hippocampus (pHPC) volume measurements are unknown.

Purpose of the Study:

  • To investigate the influence of normal aging on the uncal apex position.
  • To determine the impact of age-related uncal apex shifts on aHPC and pHPC volume calculations.
  • To evaluate alternative hippocampal segmentation methods for aging research.

Main Methods:

  • Analysis of three large datasets, totaling 4,434 hippocampi.
  • Investigation of uncal apex position relative to age.
  • Comparison of uncal apex-based segmentation with MNI space-based landmarking.

Main Results:

  • The uncal apex moves anteriorly with increasing age, particularly after age 60.
  • This anterior shift exaggerates age-related decreases in aHPC volume and underestimates pHPC volume decreases.
  • Age-related posterior hippocampal shifts also destabilize hippocampally based reference frames.

Conclusions:

  • Uncal apex and hippocampally based reference frames should be used cautiously in aging research.
  • MNI coordinate-based segmentation may be more appropriate for studies involving age-related hippocampal changes.
  • Further research into functional hippocampal divisions is needed for optimal segmentation practices.