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Prevalence and determinants of elevated D-dimer in patients with hypertrophic cardiomyopathy

Chengzhi Yang1, Changlin Zhang2, Jiansong Yuan2

  • 1Department of Cardiology and Macrovascular Disease, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Biomarkers in Medicine
|February 15, 2020
PubMed

Insights

Patients with hypertrophic cardiomyopathy (HCM) may have elevated D-dimer levels. Age, sex, and statin therapy are key factors influencing these D-dimer levels in HCM patients.

Area of Science:

  • Cardiology
  • Biomarkers

Background:

  • Hypertrophic cardiomyopathy (HCM) is a complex cardiac condition.
  • Understanding associated biomarkers like D-dimer is crucial for patient management.

Purpose of the Study:

  • To investigate D-dimer levels in patients diagnosed with hypertrophic cardiomyopathy.
  • To identify factors associated with elevated D-dimer in this population.

Main Methods:

  • Recruited 346 patients with hypertrophic cardiomyopathy (HCM).
  • Measured plasma D-dimer levels using standard laboratory methods.
  • Assessed cardiac function parameters including left ventricular mass, stroke volume, cardiac output, and cardiac index via cardiovascular magnetic resonance imaging.

Main Results:

  • 10.4% of HCM patients exhibited elevated D-dimer levels.
  • Independent predictors for elevated D-dimer included older age, female sex, and statin therapy.
  • Atrial fibrillation and diastolic blood pressure also influenced D-dimer levels.

Conclusions:

  • Plasma D-dimer levels may be elevated in patients with hypertrophic cardiomyopathy compared to healthy individuals.
  • D-dimer levels in HCM are multifactorial, influenced by demographic and clinical factors.

Keywords:
D-dimeragehypertrophic cardiomyopathysexstatin therapy

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