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Related Concept Videos

Acute Pancreatitis II: Clinical Manifestations and Management01:30

Acute Pancreatitis II: Clinical Manifestations and Management

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Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
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Acute Pancreatitis I: Introduction01:27

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Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
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Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

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The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
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Chronic Pancreatitis II: Collaborative Care01:29

Chronic Pancreatitis II: Collaborative Care

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The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
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Gastritis-II: Pathophysiology01:17

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Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
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Phase II Reactions: Acetylation Reactions01:24

Phase II Reactions: Acetylation Reactions

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Acetylation, a phase II biotransformation reaction, introduces an acetyl group to drugs or their metabolites. Acetyltransferase enzymes facilitate this reaction, which resembles α-amino acid conjugation due to the addition of a functional group to the drug molecule.
The substrates for acetylation are typically drugs or their metabolites with an amino, sulfonamide, or hydrazine functional group. Acetylation can occur at several points in the drug molecule, including primary, secondary, and...
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Related Experiment Video

Updated: Dec 28, 2025

Establishment of a Mouse Severe Acute Pancreatitis Model using Retrograde Injection of Sodium Taurocholate into the Biliopancreatic Duct
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[Acute pancreatitis under acitretin].

W Bahtaoui1, F-Z El Fetoiki1, F Hali1

  • 1Service de dermatologie, CHU Ibn Rochd, université Hassan II, Casablanca, Maroc.

Annales De Dermatologie Et De Venereologie
|February 15, 2020
PubMed
Summary
This summary is machine-generated.

Acute pancreatitis is a rare but serious adverse effect of acitretin, a systemic retinoid used for psoriasis. This case highlights the importance of considering pancreatitis in patients experiencing abdominal pain during retinoid therapy, even without high triglycerides.

Keywords:
AcitretinAcitrétinePancreatitisPancréatitePsoriasisRetinoidsRétinoïdes

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Area of Science:

  • Dermatology
  • Gastroenterology
  • Pharmacology

Background:

  • Retinoids, vitamin A derivatives, are widely used in dermatology.
  • Systemic retinoids can rarely cause acute pancreatitis.
  • Acitretin is a commonly prescribed systemic retinoid for dermatological conditions.

Observation:

  • A 27-year-old male with pustular psoriasis developed acute pancreatitis 4 days after starting acitretin (25mg/d).
  • The patient presented with severe epigastric pain and elevated serum lipase (20x normal).
  • Triglyceride levels were normal, and gallstones were absent.

Findings:

  • Acitretin was discontinued, and the patient was managed with supportive care, including parenteral feeding and fasting.
  • Serum lipase and CRP normalized within 10 days, indicating successful treatment of pancreatitis.
  • The patient later responded well to infliximab for psoriasis.

Implications:

  • Acute pancreatitis should be suspected in patients on systemic retinoids presenting with acute abdominal pain.
  • Hypertriglyceridemia is not a prerequisite for retinoid-induced pancreatitis.
  • Prompt recognition and management are crucial for favorable outcomes in this rare adverse event.