Mind-wandering in Parkinson's disease hallucinations reflects primary visual and default network coupling
Ishan C Walpola1, Alana J Muller1, Julie M Hall2
1Brain and Mind Centre and Central Clinical School, Faculty of Medicine and Health, University of Sydney, Sydney, Australia.
Summary
Patients with Parkinson's disease experiencing visual hallucinations show increased mind-wandering. This phenomenon is linked to heightened brain network coupling between visual and default networks, suggesting a role in hallucination generation.
Area of Science:
- Neuroscience
- Cognitive Psychology
- Neurology
Background:
- Visual hallucinations are common in Parkinson's disease (PD).
- The role of abstract cognition, like mind-wandering, in PD hallucinations is unclear.
- Interactions between visual and default brain networks may influence internal imagery and hallucinations.
Purpose of the Study:
- To investigate the association between mind-wandering and visual hallucinations in Parkinson's disease.
- To explore the relationship between mind-wandering, visual hallucinations, and brain network coupling in PD patients.
Main Methods:
- A thought-sampling task was used to assess mind-wandering frequency in 38 PD patients (18 with hallucinations, 20 without) and 40 controls.
- Resting-state functional magnetic resonance imaging (fMRI) was employed to examine brain network coupling.
- Inter-network connectivity and seed-to-voxel analyses were conducted.
Main Results:
- PD patients with hallucinations reported significantly higher mind-wandering frequencies than non-hallucinating PD patients.
- Non-hallucinating PD patients exhibited reduced mind-wandering compared to controls.
- Increased mind-wandering in hallucinating PD patients correlated with greater coupling between the primary visual cortex and the dorsal default network.
Conclusions:
- Mind-wandering is relatively preserved in PD patients with visual hallucinations.
- This preserved mind-wandering is associated with enhanced visual cortex-default network connectivity.
- These findings suggest that sustained abstract cognition and altered network coupling may contribute to visual hallucinations in Parkinson's disease.
Keywords:
Default networkMind-wanderingParkinson's diseaseResting state functional magnetic resonance imagingVisual hallucinationsMore Related Videos
07:26Characterizing the Relationship Between Eye Movement Parameters and Cognitive Functions in Non-demented Parkinson's Disease Patients with Eye Tracking
Published on: September 26, 2019
8.2K
14:27Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data
Published on: June 26, 2013
16.1K
Related Concept Videos
01:15Parkinson's Disease: Overview
1.6K
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
1.6K
01:26Positive Symptoms Schizophrenia: Hallucinations and Delusions
363
Schizophrenia is a complex psychiatric disorder characterized by a range of symptoms that significantly impact cognition, behavior, and emotional regulation. Among these, the positive symptoms stand out as they involve the addition or exaggeration of normal mental functions, deviating markedly from typical behavior and perception. Hallucinations and delusions are prominent positive symptoms, each profoundly affecting the individual's experience of reality.
Hallucinations
Hallucinations in...
Hallucinations
Hallucinations in...
363
01:30Positive Symptoms of Schizophrenia: Hallucinations and Delusions
442
Schizophrenia is a complex mental health disorder that can manifest with various positive symptoms, including thought, movement, and behavior disorders. These symptoms significantly disrupt cognitive and motor functions, leading to profound effects on an individual's ability to engage with the world.
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes...
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes...
442
01:37Neural Regulation
43.0K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
43.0K
01:24Parkinson's Disease: Treatment
876
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
876
01:12Visual Agnosia
792
Visual agnosia is a condition characterized by the inability to recognize visually presented objects despite having normal vision. For instance, a person with visual agnosia can describe the shape and color of an object but cannot identify or name it. This impairment does not affect their visual field, acuity, color vision, brightness discrimination, language, or memory. An example of this condition in a social setting is someone at a dinner party asking for "that silver thing with a round...
792