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Transdermal colorimetric patch for hyperglycemia sensing in diabetic mice.

Zejun Wang1, Hongjun Li1, Jinqiang Wang1

  • 1Department of Bioengineering, University of California, Los Angeles, CA, 90095, United States; California NanoSystems Institute, University of California, Los Angeles, CA, 90095, United States.

Biomaterials
|February 15, 2020
PubMed
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This study presents a novel microneedle patch for non-invasive glucose monitoring in mice. The colorimetric sensor provides instant, visible glucose level readings, improving patient compliance for diabetes management.

Area of Science:

  • Biomedical Engineering
  • Analytical Chemistry
  • Materials Science

Background:

  • Patient compliance in monitoring chronic conditions like hyperglycemia is often hindered by invasive procedures.
  • Current in-lab apparatus for metabolite readout are complex and not readily accessible for frequent monitoring.

Purpose of the Study:

  • To develop an all-in-one, transdermal colorimetric microneedle patch for the instant sensing of hyperglycemia.
  • To create a minimally invasive device for continuous glucose monitoring, enhancing patient compliance.

Main Methods:

  • Development of a microneedle patch integrating sampling and colorimetric detection of glucose.
  • Utilized a cascade enzymatic reaction involving glucose oxidase (GOx) and horseradish peroxidase (HRP) with 3,3',5,5'-tetramethylbenzidine (TMB) for color change.
Keywords:
Colorimetric sensorEnzyme biomineralizationGlucose sensorGlucose-responsiveMicroneedle

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  • Incorporated a calcium phosphate (CaP) shell around HRP for pH responsiveness and protection against non-specific reactions.

    • Main Results:

    • The microneedle patch enabled minimally invasive extraction of interstitial fluid for glucose sensing in mice.
    • Abnormally high glucose levels triggered a visible color change in the TMB indicator.
    • Quantitative glucose levels were determined by analyzing red-green-blue (RGB) information from scanned images of the microneedle.

    Conclusions:

    • The developed colorimetric microneedle sensor offers a cost-effective, portable, and non-invasive method for daily glucose level detection.
    • This technology has the potential to eliminate the need for traditional blood-drawing procedures in glucose monitoring.