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Relationship between urinary bisphenol a levels and cardiovascular diseases in the U.S. adult population, 2003-2014
Shaofang Cai1, Xianming Rao2, Jianhong Ye2
1Department of Science and Education, The Second Affiliated Hospital of Xiamen Medical College, Xiamen, China.
Insights
This study links higher urinary Bisphenol A (BPA) levels to increased risks of heart attack and stroke. These findings highlight BPA as a potential risk factor for cardiovascular disease, especially in men.
Area of Science:
- Environmental health
- Cardiovascular disease epidemiology
- Toxicology
Background:
- Emerging evidence suggests Bisphenol A (BPA) impacts the cardiovascular system.
- Previous studies explored BPA links to cardiovascular diseases (CVD) and risk factors.
- No prior research investigated the association between urinary BPA and stroke risk.
Purpose of the Study:
- To examine the relationship between urinary BPA concentrations and the prevalence of stroke.
- To investigate the association between BPA and other cardiovascular outcomes.
Main Methods:
- Utilized data from the U.S. National Health and Nutrition Examination Surveys (NHANES) (2003-2014).
- Included a representative sample of 9,139 adults aged 20 years and older.
- Employed multivariable logistic regression to analyze BPA levels and CVD outcomes.
Main Results:
- Elevated urinary BPA levels correlated with increased prevalence of myocardial infarction (MI) and stroke.
- Each unit increase in BPA concentration was associated with higher odds of congestive heart failure, coronary heart disease (CHD), angina pectoris, MI, stroke, and total CVD.
- Associations were more pronounced in males compared to females.
Conclusions:
- This study provides initial evidence of a positive association between urinary BPA concentration and stroke in the U.S. population.
- Urinary BPA levels are positively correlated with multiple CVD outcomes, particularly in men.
- Further prospective studies are needed to confirm the human health effects of BPA on CVD.
Background:
Emerging evidence has identified cardiovascular system as a potential target of Bisphenol A (BPA). Although a few studies have revealed the relationship between BPA and the risk of several cardiovascular diseases (CVD) outcomes and CVD risk factors, no published studies have investigated the link between urinary BPA and the risk of stroke.
Methods:
Data were derived from the United States National Health and Nutrition Examination Surveys (NHANES), with a representative sample aged ≥20 years (n = 9139) from 2003 to 2014. We performed multivariable logistic regression model to estimate associations between quartiles and natural logarithm transformed urinary BPA concentrations and five specific CVD outcomes and total CVD.
Results:
In quartile analysis, highest level of urinary BPA was associated with increased prevalence of myocardial infarction (MI) (OR = 1.73, 95% CI = 1.11-2.69) and stroke (OR = 1.61, 95% CI = 1.09-2.36), when compared with those at the lowest quartile. Per unit (μg/g creatinine) increment in ln-transformed BPA concentration was shown to be significantly associated with 19%, 19%, 25%, 29%, 20%, and 16% increased odds ratios of prevalence of congestive heart failure, coronary heart disease (CHD), angina pectoris, MI, stroke and total CVD among total participants, respectively. Similar associations were found in males rather than in females.
Conclusion:
We provided the premier evidence of positive relationship between urinary BPA concentration and stroke in U.S.
Population:
Urinary BPA levels were also positively correlated with congestive heart failure, CHD, angina pectoris, MI, as well as total CVD. These associations were more evident in males. Well-coordinated and prospective studies are warranted to gain the human effects of BPA on CVD.
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