Related Experiment Video

Updated: Dec 28, 2025

Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.6K

Serum uromodulin and risk for cardiovascular morbidity and mortality in the community-based KORA F4 study

Cornelia Then1, Holger L Then2, Andreas Lechner3

  • 1Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, LMU München, Germany; Clinical Cooperation Group Diabetes, Ludwig-Maximilians-Universität München and Helmholtz Zentrum München, Munich, Germany.

Atherosclerosis
|February 15, 2020
PubMed

Insights

Serum uromodulin, a kidney function biomarker, predicts mortality in older men. Higher levels were linked to lower total and cardiovascular death risk in men but not women in a population study.

Area of Science:

  • Nephrology
  • Cardiology
  • Epidemiology

Background:

  • Serum uromodulin is a novel biomarker for kidney function and tubular integrity.
  • Previous studies suggest a link between serum uromodulin and cardiovascular events and mortality in high-risk populations.

Purpose of the Study:

  • To investigate the association between serum uromodulin levels and cardiovascular morbidity and mortality.
  • To analyze these associations stratified by sex in a general population cohort.

Main Methods:

  • Serum uromodulin was measured in 1079 participants (aged 62-81 years) of the population-based KORA F4 study.
  • Cox proportional hazards models were used to analyze associations with mortality and cardiovascular events over 8.4-8.6 years of follow-up.
  • Analyses were adjusted for age, BMI, diabetes, and estimated glomerular filtration rate (eGFR).

Main Results:

  • Serum uromodulin was inversely associated with total mortality (HR 0.65) and cardiovascular mortality (HR 0.70) in men, but not in women.
  • An inverse association was observed between serum uromodulin and incident stroke in men (HR 0.68), but not in women.
  • Associations with incident myocardial infarction were not significant after multivariable adjustment in either sex.

Conclusions:

  • Serum uromodulin is an independent predictor of total and cardiovascular mortality in men aged 62 years and older from the general community.
  • The predictive value of serum uromodulin for mortality and cardiovascular events may differ between sexes.
Abstract

Keywords:
Cardiovascular eventsMyocardial infarctionSerum uromodulinStrokeTotal mortalitysUmod

More Related Videos

A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy07:52

A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy

Published on: November 7, 2017

21.7K
Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome06:04

Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome

Published on: September 27, 2024

1.4K

Related Concept Videos

Serum Studies: Renal Function Tests01:24

Serum Studies: Renal Function Tests

Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
301
Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
381
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
540
Urodynamic Studies: Uroflowmetry01:19

Urodynamic Studies: Uroflowmetry

Uroflowmetry is a non-invasive urodynamic test designed to measure various aspects of urination, including volume, flow rate, and the time to void. This test is crucial for diagnosing and assessing conditions such as bladder outlet obstruction, bladder dysfunction, incomplete bladder emptying, incontinence, and urinary tract blockages caused by benign prostatic hyperplasia (BPH) and urethral strictures.Pre-Test Instructions:Before a uroflowmetry test, patients are typically advised to drink...
2.5K
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
473
Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration01:28

Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration

Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area.
124