Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Anatomically-guided masked autoencoder pre-training for aneurysm detection.

IEEE Winter Conference on Applications of Computer Vision. IEEE Winter Conference on Applications of Computer Vision·2026
Same author

An Immediate-Response Detection System for γ-Hydroxybutyrate to Enhance Personal Safety in Social Environments.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Temporal immunomodulation of CD4<sup>+</sup> T cells by magnesium regulates osteoimmune responses in osteoporotic fracture healing.

Science advances·2026
Same author

Biomechanical Comparison of Lumbar, Sacral and Iliac Screw Strain with the Novel Eiffel Tower Configuration Versus Conventional Pelvic Fixation in Adult Spinal Deformity Surgery.

Journal of surgical orthopaedic advances·2026
Same author

A Bayesian approach to estimate ambient dose equivalent for liquid radioactive waste measurements.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine·2026
Same author

Dietary intake patterns and nutritional adequacy in older adults with predialysis chronic kidney disease: a comparison by diabetes status.

Clinical nutrition research·2026

Related Experiment Video

Updated: Dec 28, 2025

3D Hydrogel Scaffolds for Articular Chondrocyte Culture and Cartilage Generation
12:37

3D Hydrogel Scaffolds for Articular Chondrocyte Culture and Cartilage Generation

Published on: October 7, 2015

20.5K

Inflammation-Modulating Hydrogels for Osteoarthritis Cartilage Tissue Engineering.

Rachel H Koh1, Yinji Jin1, Jisoo Kim1

  • 1School of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, Seoul 08826, Korea.

Cells
|February 16, 2020
PubMed
Summary

Osteoarthritis (OA) treatment is advancing with immunomodulatory biomaterials and hydrogels. These therapies aim to control joint inflammation and regenerate cartilage for improved patient outcomes.

Keywords:
anti-inflammatorycartilagedrug deliveryimmune-modulationinjectable hydrogeltissue engineering

More Related Videos

Mechanical Stimulation of Chondrocyte-agarose Hydrogels
12:45

Mechanical Stimulation of Chondrocyte-agarose Hydrogels

Published on: October 27, 2012

12.0K
Creation of a Knee Joint-on-a-Chip for Modeling Joint Diseases and Testing Drugs
12:44

Creation of a Knee Joint-on-a-Chip for Modeling Joint Diseases and Testing Drugs

Published on: January 27, 2023

4.3K

Related Experiment Videos

Last Updated: Dec 28, 2025

3D Hydrogel Scaffolds for Articular Chondrocyte Culture and Cartilage Generation
12:37

3D Hydrogel Scaffolds for Articular Chondrocyte Culture and Cartilage Generation

Published on: October 7, 2015

20.5K
Mechanical Stimulation of Chondrocyte-agarose Hydrogels
12:45

Mechanical Stimulation of Chondrocyte-agarose Hydrogels

Published on: October 27, 2012

12.0K
Creation of a Knee Joint-on-a-Chip for Modeling Joint Diseases and Testing Drugs
12:44

Creation of a Knee Joint-on-a-Chip for Modeling Joint Diseases and Testing Drugs

Published on: January 27, 2023

4.3K

Area of Science:

  • Biomaterials Science
  • Immunology
  • Orthopedics

Background:

  • Osteoarthritis (OA) is a prevalent, disabling joint disease characterized by cartilage deterioration and inflammation.
  • Current understanding of OA pathophysiology remains incomplete, highlighting the need for novel therapeutic strategies.
  • Inflammation is a key driver in OA onset and progression, necessitating localized anti-inflammatory treatments.

Purpose of the Study:

  • To review current and future immunomodulatory therapies for osteoarthritis.
  • To explore the potential of hydrogels in OA treatment beyond drug delivery.
  • To discuss cartilage-regenerative injectable and adhesive hydrogels for OA therapy.

Main Methods:

  • Review of existing literature on OA pathophysiology and treatment modalities.
  • Analysis of immunomodulatory biomaterials and their potential translation to OA therapy.
  • Examination of hydrogel properties for sustained release, immunomodulation, and cartilage regeneration.

Main Results:

  • Hydrogels can provide sustained release of therapeutics and possess inherent immunomodulatory functions.
  • Immunomodulatory biomaterials, developed for other applications, show promise for OA treatment.
  • Injectable and adhesive hydrogels can promote cartilage tissue regeneration by restoring chondrocyte function.

Conclusions:

  • Combining immunomodulatory tissue engineering with regenerative hydrogels offers robust potential for OA treatment.
  • Future OA therapies may involve biomaterials that regulate immune responses and stimulate cartilage repair.
  • Targeting inflammation and promoting matrix synthesis are crucial for reversing OA-induced damage.