Related Experiment Video

Updated: Dec 28, 2025

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
09:02

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion

Published on: February 2, 2021

4.8K

Low dose of flurbiprofen axetil decrease the rate of acute kidney injury after operation: a retrospective clinical

Dong Wang1, Shi-Kun Yang2, Meng-Xi Zhao1

  • 1Department of Anesthesiology, The Third Xiangya Hospital of Central South University, 138, Tongzipo Road, Changsha, Hunan, China.

BMC Nephrology
|February 16, 2020
PubMed
Abstract

Insights

Low-dose flurbiprofen axetil (FA) may reduce postoperative acute kidney injury (AKI), while high-dose FA increases AKI risk. This dose-dependent relationship highlights the importance of careful perioperative FA administration for kidney protection.

Area of Science:

  • Anesthesiology and Perioperative Medicine
  • Nephrology and Kidney Diseases
  • Pharmacology and Therapeutics

Background:

  • Flurbiprofen axetil (FA) is widely used for perioperative pain management.
  • The association between FA dosage and postoperative acute kidney injury (AKI) is not well-established.
  • Understanding this relationship is crucial for patient safety during and after surgery.

Purpose of the Study:

  • To investigate the dose-dependent effects of perioperative flurbiprofen axetil (FA) on the incidence of postoperative acute kidney injury (AKI).
  • To determine if different dosages of FA influence the risk of developing AKI after surgery.
  • To provide evidence-based recommendations for FA use in the perioperative period.

Main Methods:

  • Retrospective analysis of 9915 patients undergoing surgery.
  • Categorization of patients based on perioperative flurbiprofen axetil (FA) dosage: non-use, low dose (50-100 mg), middle dose (100-250 mg), and large dose (≥250 mg).
  • Statistical analysis using univariable and multivariate logistic regression to assess the impact of FA dosage on AKI prevalence.

Main Results:

  • The overall incidence of postoperative AKI was 6.7%.
  • Low-dose FA (50-100 mg) was associated with a significantly lower AKI incidence (4.5%) compared to non-use (7.2%, P < 0.001).
  • Large-dose FA (≥250 mg) showed a significantly higher AKI incidence (18.8%) compared to non-use (7.2%, P < 0.001), indicating a dose-dependent risk.

Conclusions:

  • The effect of flurbiprofen axetil (FA) on postoperative acute kidney injury (AKI) is dose-dependent.
  • Perioperative use of low-dose FA (50-100 mg) may be protective against AKI.
  • High-dose FA (≥250 mg) is a significant risk factor for postoperative AKI.
Keywords:
Acute kidney injuryFlurbiprofenOperationRetrospective study

More Related Videos

Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research03:13

Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research

Published on: November 3, 2023

2.8K
Unilateral Ureteral Obstruction Model for Investigating Kidney Interstitial Fibrosis04:37

Unilateral Ureteral Obstruction Model for Investigating Kidney Interstitial Fibrosis

Published on: April 25, 2025

1.3K

Related Concept Videos

Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
217
Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
228
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
238
Acute Kidney Injury I: Introduction01:22

Acute Kidney Injury I: Introduction

Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
449
Acute Kidney Injury VI: Nursing Management01:22

Acute Kidney Injury VI: Nursing Management

Acute Kidney Injury (AKI) results in an inability to maintain fluid, electrolyte, and acid-base balance. Effective nursing management is critical in improving patient outcomes and includes comprehensive patient assessment and targeted interventions.Comprehensive Patient AssessmentA detailed history collection is essential, focusing on any recent infections, nephrotoxic medication use, or chronic conditions such as hypertension and diabetes that may contribute to AKI. During the physical...
304
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
762