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Laboratory-based Intermountain Validated Exacerbation (LIVE) Score stability in patients with chronic obstructive
Denitza P Blagev1,2, Dave S Collingridge3, Susan Rea3
1Pulmonary and Critical Care Medicine, Intermountain Medical Center, Murray, Utah, USA denitza.blagev@imail.org.
BMJ Open Respiratory Research
|February 16, 2020
Summary
The Laboratory-based Intermountain Validated Exacerbation (LIVE) Score identifies stable low-risk and unstable high-risk patients with chronic obstructive pulmonary disease (COPD). High-risk COPD patients often transition to lower risk categories over time.
Area of Science:
- Pulmonary Medicine
- Health Services Research
Background:
- The Laboratory-based Intermountain Validated Exacerbation (LIVE) Score predicts mortality and exacerbation risk in patients with chronic obstructive pulmonary disease (COPD).
- The stability of the LIVE Score as a patient characteristic across different health systems has not been previously established.
Purpose of the Study:
- To validate the LIVE Score in a new health system.
- To assess the temporal stability of the LIVE Score in a large cohort of COPD patients.
Main Methods:
- Validation of the LIVE Score in a fourth health system.
- Retrospective analysis of 98,766 COPD patients across four health systems.
- Assessment of LIVE Score changes over a 4-year period, defining stability as a majority of survivors retaining the same score.
Main Results:
- The LIVE Score effectively stratified patients into low, medium, and high mortality risk groups.
- Low-risk LIVE Score groups demonstrated stability over time.
- High-risk LIVE Score groups were unstable, with a significant proportion of patients transitioning to medium or low-risk categories within 4 years.
Conclusions:
- The LIVE Score identifies distinct, clinically actionable patient cohorts: stable low-risk, unstable high-risk, and medium-risk.
- Findings enhance understanding of LIVE Score dynamics and inform targeted interventions for COPD patients within health systems.
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