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Eosinophils, basophils and type 2 immune microenvironments in COPD-affected lung tissue
Prajakta Jogdand1, Premkumar Siddhuraj1, Michiko Mori1
1Dept of Experimental Medical Science, Lund University, Lund, Sweden.
The European Respiratory Journal
|February 16, 2020
Summary
In chronic obstructive pulmonary disease (COPD), eosinophils and basophils infiltrate lung tissues, forming patchy, localized immune microenvironments. This discovery offers new insights into COPD
Area of Science:
- Pulmonary immunology
- Cellular pathology in respiratory diseases
Background:
- Elevated eosinophils are common in COPD, but their lung distribution is unclear.
- Basophils in COPD pathogenesis remain largely uninvestigated.
Purpose of the Study:
- To map tissue-infiltrating eosinophils and basophils in COPD lungs.
- To investigate eosinophil-promoting immune mechanisms and their anatomical distribution in COPD.
Main Methods:
- Surgical lung tissues and biopsies from COPD patients (GOLD stages I-IV) and controls were analyzed.
- Automated immunohistochemistry and in situ hybridization identified immune cells, GATA3, and eotaxins (CCL11, CCL24).
Main Results:
- Eosinophils and basophils were found in all lung compartments, increasing with COPD severity.
- Patchy eosinophilia was linked to GATA3+ cells, forming type 2 immune microenvironments.
- Localized eotaxin expression was observed in both COPD patients and influenza-infected mice.
Conclusions:
- Tissue basophilia is a novel feature of advanced COPD.
- Spatially confined eosinophil-rich type 2 microenvironments represent a new aspect of COPD immunopathology.
- Findings suggest potential for personalized COPD treatment strategies.
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