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Reproducible research practices, openness and transparency in health economic evaluations: study protocol for a
Ferrán Catalá-López1,2,3, Lisa Caulley3,4,5,6, Manuel Ridao7
1Department of Health Planning and Economics, National School of Public Health, Institute of Health Carlos III, Madrid, Spain ferran_catala@outlook.com.
This study assesses transparency and reproducibility in health economic evaluations. Findings will guide improvements in reporting standards for better research reliability.
Area of Science:
- Health Economics
- Research Methodology
- Scientific Transparency
Background:
- Growing need for rigorous and transparent health research to ensure reproducibility.
- Health economic evaluations are crucial for informing healthcare decision-making.
- Assessing the current state of transparency and reproducibility in published health economic evaluations is essential.
Purpose of the Study:
- To investigate the extent to which health economic evaluation articles promote transparency, openness, and reproducibility.
- To analyze trends in reporting practices over time.
- To identify factors influencing the adoption of reproducible research practices.
Main Methods:
- Cross-sectional comparative analysis of 600 cost-effectiveness analysis publications indexed in MEDLINE (2012, 2019, 2022).
- Inclusion of English-written papers reporting incremental cost-effectiveness ratios (ICERs) with specific outcome measures.
- Standardized data extraction by multiple researchers, with duplicate extraction for a subset to ensure reliability.
Main Results:
- Reporting of general, methodological, and reproducibility items will be extracted and analyzed.
- Data will be stratified by publication year, adherence to Consolidated Health Economic Evaluation Reporting Standards (CHEERS), and journal.
- Risk ratios will be calculated to assess changes in reporting practices between 2012-2019 and 2019-2022.
Conclusions:
- Findings will highlight the current level of transparency and reproducibility in health economic evaluations.
- The study will provide insights into the effectiveness of reporting guidelines like CHEERS.
- Results will inform recommendations for enhancing research integrity and decision-making in healthcare economics.
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