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Updated: Dec 28, 2025
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Preclinical Model of Prenatal Delta-9-Tetrahydrocannabinol Exposure to Assess Its Impact on Neurodevelopmental Outcomes
Published on: February 28, 2025
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Cannabis use during pregnancy and postpartum.
Sophia Badowski1, Graeme Smith2
1Resident in obstetrics and gynecology at Queen's University in Kingston, Ont. slenson@qmed.ca.
Canadian Family Physician Medecin De Famille Canadien
|February 16, 2020
Summary
Cannabis use during pregnancy and breastfeeding poses risks to infant neurodevelopment. Healthcare providers should advise patients against using cannabis for nausea and vomiting due to potential long-term adverse effects.
Area of Science:
- Obstetrics and Gynecology
- Neurodevelopmental Pediatrics
- Clinical Pharmacology
Background:
- Cannabis use during pregnancy and lactation is a growing concern for obstetric care providers.
- Patient education on the risks of cannabis exposure and its association with nausea and vomiting in pregnancy (NVP) is crucial.
Observation:
- In utero cannabis exposure is linked to persistent neurodevelopmental deficits into young adulthood.
- Cannabis is not recommended for treating NVP and may lead to cannabinoid hyperemesis syndrome with chronic use.
Findings:
- No safe threshold for cannabis consumption exists during pregnancy or lactation.
- Counseling pregnant and breastfeeding individuals on risks is essential.
Implications:
- Healthcare providers must counsel patients on the risks of prenatal and postnatal cannabis exposure.
- Encouraging abstinence from cannabis during pregnancy and breastfeeding is paramount for infant well-being.
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