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Related Experiment Video

Updated: Dec 28, 2025

Optogenetic Stimulation of the Auditory Nerve
10:53

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Published on: October 8, 2014

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Optoacoustic brain stimulation at submillimeter spatial precision.

Ying Jiang1,2, Hyeon Jeong Lee2,3,4,5,6, Lu Lan2,5

  • 1Graduate Program for Neuroscience, Boston University, Boston, MA, 02215, USA.

Nature Communications
|February 16, 2020
PubMed
Summary

Researchers developed a miniaturized Fiber-Optoacoustic Converter (FOC) for precise neural stimulation. This novel device offers superior spatial resolution compared to traditional methods, enabling targeted neuromodulation and motor activity control in vivo.

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Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Acoustic Physics

Background:

  • Low-intensity ultrasound is a promising neuromodulation technique.
  • Conventional methods lack spatial precision and are bulky.
  • Existing technologies hinder wearable applications and multimodal integration.

Purpose of the Study:

  • To introduce a miniaturized Fiber-Optoacoustic Converter (FOC) for precise neural stimulation.
  • To overcome the limitations of spatial confinement and size in current neuromodulation tools.
  • To demonstrate the efficacy of FOC for in vitro and in vivo neural activation.

Main Methods:

  • Development of a 600 μm diameter Fiber-Optoacoustic Converter (FOC).
  • Utilizing the optoacoustic effect for localized ultrasound generation at the fiber tip.
  • Testing FOC for activating cultured neurons and monitoring intracellular Ca2+ transients.
  • In vivo experiments on mouse brains to assess neural stimulation and motor activity modulation.

Main Results:

  • FOC successfully activated individual cultured neurons and induced Ca2+ transients.
  • Achieved spatially confined neural activation within a 500 μm radius.
  • Demonstrated superior spatial resolution compared to piezo-based transducers.
  • Successfully stimulated mouse brains and modulated motor activity in vivo.

Conclusions:

  • The miniaturized FOC enables highly spatially confined optoacoustic neural stimulation.
  • FOC technology offers significant advantages in spatial resolution and miniaturization over conventional methods.
  • This approach holds potential for advanced wearable neuromodulation and integrated experimental setups.