Related Experiment Video
Updated: Dec 28, 2025
10:07
"Phagosome Closure Assay" to Visualize Phagosome Formation in Three Dimensions Using Total Internal Reflection Fluorescent Microscopy TIRFM
Published on: August 26, 2016
6.9K
C-Type Lectin Receptors in Phagocytosis
Kai Li1,2, David M Underhill3,4
1F. Widjaja Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA.
Current Topics in Microbiology and Immunology
|February 16, 2020
Summary
C-type lectin receptors (CLRs) are key transmembrane proteins that initiate innate immune responses. This review explores how CLRs regulate phagocytosis in immune cells like macrophages and neutrophils.
Area of Science:
- Immunology
- Cell Biology
Background:
- C-type lectin receptors (CLRs) are transmembrane proteins with a C-type lectin-like domain (CTLD).
- CLRs interact with signaling molecules like the Fc receptor common gamma chain (FcRγ).
- Many CLRs recognize microbial cell walls, activating innate immunity.
Purpose of the Study:
- To review the role of CLRs in phagocytosis.
- To examine CLR contributions to immune cell activation and regulation.
Main Methods:
- Literature review of CLR function in phagocytosis.
Main Results:
- CLRs are crucial for activating inflammatory and antimicrobial responses.
- Specific CLRs modulate phagocytosis in macrophages, dendritic cells, and neutrophils.
Conclusions:
- CLRs play a significant role in phagocytosis regulation.
- Understanding CLR function is vital for innate immunity research.
Related Concept Videos
00:41Phagocytosis
92.4K
Cells pull particles inward and engulf them in spherical vesicles in an energy-requiring process called endocytosis. Phagocytosis (“cellular eating”) is one of three major types of endocytosis. Cells use phagocytosis to take in large objects—such as other cells (or their debris), bacteria, and even viruses.
92.4K
00:41Phagocytosis
7.5K
Cells pull particles inward and engulf them in spherical vesicles in an energy-requiring process called endocytosis. Phagocytosis ("cellular eating") is one of three major types of endocytosis. Cells use phagocytosis to take in large objects, such as other cells (or their debris), bacteria, and even viruses.
The objective of phagocytosis is often destruction. Cells use phagocytosis to eliminate unwelcome visitors, like pathogens (e.g., viruses and bacteria). Many immune system cells,...
The objective of phagocytosis is often destruction. Cells use phagocytosis to eliminate unwelcome visitors, like pathogens (e.g., viruses and bacteria). Many immune system cells,...
7.5K
01:39Receptor-mediated Endocytosis
110.1K
Overview
110.1K
01:20Receptor-mediated Endocytosis
7.3K
Receptor-mediated endocytosis is when bulk amounts of specific molecules are imported into a cell after binding to cell surface receptors. The molecules bound to these receptors are taken into the cell through inward folding of the cell surface membrane, which is eventually pinched off into a vesicle within the cell. Structural proteins, such as clathrin, coat the budding vesicle.
Clathrin-Mediated Endocytosis of LDL
One well-characterized example of receptor-mediated endocytosis is the...
Clathrin-Mediated Endocytosis of LDL
One well-characterized example of receptor-mediated endocytosis is the...
7.3K
01:17Phagocytosis of Apoptotic Cells
4.8K
Cells undergoing apoptosis form apoptotic bodies that must be removed immediately to prevent inflammation, autoimmune diseases, and necrosis. Phagocytosis is carried out by professional phagocytes such as macrophages or immature dendritic cells. Non-professional phagocytes such as epithelial cells and fibroblasts also take part in this process; however, they are not as effective as professional phagocytes.
Normal cells contain receptors that prevent them from being recognized...
Normal cells contain receptors that prevent them from being recognized...
4.8K
01:25Immune Surveillance by NK Cells and Phagocytes
7.7K
Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
7.7K