Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

6.0K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
6.0K
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

7.6K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
7.6K
Skin Cancer01:30

Skin Cancer

5.6K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
5.6K
Metastasis02:30

Metastasis

6.3K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
6.3K
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

4.6K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
4.6K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

8.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The SIRT Family: Subcellular Localization and Main Functions.

International journal of molecular sciences·2026
Same author

Correlation Between Molecular Genetic Analysis and Nuclear Pleomorphism in Long-Term Recurrent and Metastatic Chordoma.

Cancers·2026
Same author

The European Organisation for Research and Treatment of Cancer Pathobiology group and the young task force: A pan-tumor framework for translational oncology.

The International journal of biological markers·2026
Same author

Histone deacetylase in human sarcomas.

The International journal of biological markers·2025
Same author

A Lymphotoxin-Driven Pathway to Hepatocellular Carcinoma.

Cancer cell·2025
Same author

Neuropathological Characterisation of McLeod Syndrome With a Proposed New Grading System.

Neuropathology and applied neurobiology·2025

Related Experiment Video

Updated: Dec 28, 2025

In Vivo Model for Testing Effect of Hypoxia on Tumor Metastasis
12:03

In Vivo Model for Testing Effect of Hypoxia on Tumor Metastasis

Published on: December 9, 2016

12.8K

[Malignant round cell tumors : The Ewing sarcoma and beyond].

Johannes Haybaeck1,2,3, Albert Roessner4

  • 1Institut für Pathologie, Univ.-Klinikum Magdeburg A.ö.R., Medizinische Fakultät, Otto-von-Guericke-Universität Magdeburg, Leipziger Straße 44, 39120, Magdeburg, Deutschland. johannes.haybaeck@med.ovgu.de.

Der Pathologe
|February 16, 2020
PubMed
Summary

Accurate classification of Ewing sarcoma family tumors is crucial for prognosis. Molecular genetic profiling, while not altering current treatments, aids in predicting outcomes and personalizing future therapies for these rare childhood cancers.

Keywords:
Atypical variantsEwing sarcomaFusion oncoproteinMolecular geneticsNew therapy approaches

More Related Videos

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors
08:57

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors

Published on: May 17, 2024

2.4K
Tumorsphere Derivation and Treatment from Primary Tumor Cells Isolated from Mouse Rhabdomyosarcomas
09:21

Tumorsphere Derivation and Treatment from Primary Tumor Cells Isolated from Mouse Rhabdomyosarcomas

Published on: September 13, 2019

7.5K

Related Experiment Videos

Last Updated: Dec 28, 2025

In Vivo Model for Testing Effect of Hypoxia on Tumor Metastasis
12:03

In Vivo Model for Testing Effect of Hypoxia on Tumor Metastasis

Published on: December 9, 2016

12.8K
Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors
08:57

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors

Published on: May 17, 2024

2.4K
Tumorsphere Derivation and Treatment from Primary Tumor Cells Isolated from Mouse Rhabdomyosarcomas
09:21

Tumorsphere Derivation and Treatment from Primary Tumor Cells Isolated from Mouse Rhabdomyosarcomas

Published on: September 13, 2019

7.5K

Area of Science:

  • Pediatric Oncology
  • Molecular Pathology
  • Cancer Genetics

Background:

  • Ewing sarcoma is a highly malignant tumor predominantly affecting children and adolescents.
  • Accurate diagnosis relies on clinical, histopathological, and molecular genetic evaluation.
  • While EWSR1-FLI1 fusion is common, other Ewing sarcoma family members mimic classical Ewing sarcoma histopathologically but have distinct genetic profiles.

Purpose of the Study:

  • To highlight the importance of precise molecular genetic classification within the Ewing sarcoma family.
  • To discuss the implications of distinct genetic profiles in Ewing sarcoma subtypes.
  • To explore the future role of molecular diagnostics in personalized medicine for Ewing sarcoma.

Main Methods:

  • Histopathological examination of small round blue cell tumors.
  • Immunohistochemical analysis for tumor characterization.
  • Molecular genetic profiling to identify specific genetic alterations, including EWSR1-FLI1 fusions and other rearrangements.

Main Results:

  • Identified that not all Ewing sarcoma family tumors exhibit the common EWSR1-FLI1 fusion.
  • Demonstrated that distinct molecular genetic profiles exist among Ewing sarcoma family members.
  • Confirmed that histopathological and immunohistochemical methods alone may not differentiate all subtypes.

Conclusions:

  • Precise molecular genetic classification is essential for understanding Ewing sarcoma heterogeneity.
  • Current standard treatments for Ewing sarcoma remain unchanged by detailed molecular subtyping.
  • Molecular profiling offers prognostic value and is key to future personalized medicine strategies for Ewing sarcoma.