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Related Concept Videos

Notch Signaling Pathway03:14

Notch Signaling Pathway

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The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
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Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

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Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
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The Cochlea01:13

The Cochlea

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The cochlea is a coiled structure in the inner ear that contains hair cells—the sensory receptors of the auditory system. Sound waves are transmitted to the cochlea by small bones attached to the eardrum called the ossicles, which vibrate the oval window that leads to the inner ear. This causes fluid in the chambers of the cochlea to move, vibrating the basilar membrane.
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Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

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The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
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Determination01:51

Determination

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During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In...
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Hair Cells01:22

Hair Cells

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Hair cells are the sensory receptors of the auditory system—they transduce mechanical sound waves into electrical energy that the nervous system can understand. Hair cells are located in the organ of Corti within the cochlea of the inner ear, between the basilar and tectorial membranes. The actual sensory receptors are called inner hair cells. The outer hair cells serve other functions, such as sound amplification in the cochlea, and are not discussed in detail here.
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Related Experiment Video

Updated: Dec 28, 2025

Real-time Bioluminescence Imaging of Notch Signaling Dynamics during Murine Neurogenesis
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Real-time Bioluminescence Imaging of Notch Signaling Dynamics during Murine Neurogenesis

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Notch Signalling: The Multitask Manager of Inner Ear Development and Regeneration.

Nicolas Daudet1, Magdalena Żak2

  • 1University College London, The Ear Institute, London, UK. n.daudet@ucl.ac.uk.

Advances in Experimental Medicine and Biology
|February 16, 2020
PubMed
Summary

Notch signalling regulates cell fate through lateral inhibition and induction. This pathway is crucial for vertebrate inner ear development and regeneration, offering therapeutic targets for hearing loss.

Keywords:
Cell fate decisionsCochleaDeafnessDevelopmentHair cellHair cell regenerationInner earLateral inductionLateral inhibitionNotch signallingOrgan of CortiProneural genesProsensory specification

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Area of Science:

  • Developmental Biology
  • Cell Signalling
  • Regenerative Medicine

Background:

  • Notch signalling is a conserved pathway regulating cell fate and tissue patterning in metazoans.
  • It operates via lateral inhibition (competitive interactions) and lateral induction (cooperative interactions).
  • Understanding Notch signalling is key to comprehending developmental processes and potential regenerative strategies.

Purpose of the Study:

  • To introduce the two modes of Notch signalling: lateral inhibition and lateral induction.
  • To explain their roles in vertebrate inner ear development and regeneration.
  • To discuss factors influencing context-specific Notch outcomes and therapeutic potential.

Main Methods:

  • Literature review and synthesis of existing research on Notch signalling.
  • Comparative analysis of Notch function in different developmental contexts.
  • Discussion of factors influencing signalling outcomes and therapeutic targeting.

Main Results:

  • Notch signalling employs both competitive (inhibition) and cooperative (induction) mechanisms.
  • These modes differentially contribute to inner ear development and regeneration.
  • Specific factors can modulate Notch pathway activity in a context-dependent manner.

Conclusions:

  • Notch signalling's dual modes are fundamental to inner ear development and regeneration.
  • Targeting Notch pathways holds promise for treating hearing loss and vestibular disorders.
  • Further research is needed to elucidate context-specific signalling and optimize therapeutic strategies.