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IL-17 Signaling in the Tumor Microenvironment
1Department of Surgery & Immunology, University of Toronto, Toronto, ON, Canada. reg.gorczynski@utoronto.ca.
Advances in Experimental Medicine and Biology
|February 16, 2020
Summary
Interleukin 17 (IL-17) and its receptor (IL-17R) play a complex role in the tumor microenvironment, influencing cancer growth and metastasis. Understanding these interactions offers potential new therapeutic strategies.
Area of Science:
- Oncology
- Immunology
- Cell Biology
Background:
- Inflammation's dual role in tumor growth: promoting or inhibiting cancer progression.
- The tumor microenvironment (TME) is shaped by extracellular signals from various cells.
- Focus on the pro-inflammatory cytokine Interleukin 17 (IL-17) and its producing cells (Th17, non-T cells) within the TME.
Purpose of the Study:
- To review the current understanding of IL-17/IL-17R signaling in the tumor microenvironment.
- To explore the impact of IL-17/IL-17R on tumor growth and metastasis.
- To highlight potential clinical applications of this knowledge.
Main Methods:
- Literature review and synthesis of existing research on IL-17 and IL-17R in cancer.
- Analysis of the IL-17 cytokine family and its receptor variants (IL-17RA-RE).
- Discussion of cellular sources and targets of IL-17 signaling within the TME.
Main Results:
- IL-17 family members (IL-17A-F) signal through IL-17 receptors (IL-17RA-RE).
- IL-17/IL-17R interactions are implicated in modulating tumor growth and metastatic potential.
- These interactions are influenced by diverse cell types within the TME.
Conclusions:
- IL-17/IL-17R signaling is a critical component of the tumor microenvironment.
- Targeting IL-17 pathways may offer novel therapeutic avenues for cancer treatment.
- Further research is needed to fully elucidate and exploit these mechanisms in clinical settings.
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