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Intracranial hypertension and cortical thickness in syndromic craniosynostosis

Alexander T Wilson1,2, Bianca K Den Ottelander1, Robbin De Goederen1

  • 1Department of Plastic and Reconstructive Surgery, Erasmus Medical Center, Rotterdam, the Netherlands.

Developmental Medicine and Child Neurology
|February 16, 2020
PubMed

Insights

Papilloedema and hydrocephalus are linked to reduced cerebral cortex thickness in syndromic craniosynostosis. Early detection of these risk factors is crucial for timely intervention and better patient outcomes.

Area of Science:

  • Neurology
  • Pediatric Neurosurgery
  • Radiology

Background:

  • Syndromic craniosynostosis involves premature fusion of cranial sutures, potentially leading to intracranial hypertension (ICH).
  • Cerebral cortex thickness is a potential biomarker for neurological compromise in these patients.
  • Identifying ICH risk factors impacting cortical thickness is vital for managing syndromic craniosynostosis.

Purpose of the Study:

  • To investigate the association between intracranial hypertension risk factors and cerebral cortex thickness.
  • To determine if specific ICH risk factors correlate with changes in cortical thickness in patients with syndromic craniosynostosis.

Main Methods:

  • Retrospective analysis of magnetic resonance images from 107 patients with syndromic craniosynostosis.
  • Evaluation of ICH risk factors: papilloedema, hydrocephalus, obstructive sleep apnea (OSA), cerebellar tonsillar position, OFC, age, and sex.
  • Statistical analysis using a linear mixed model to assess correlations with cerebral cortex thickness.

Main Results:

  • Papilloedema and hydrocephalus were independently associated with thinner cerebral cortex (p=0.036 and p=0.007, respectively).
  • Cortical thickness did not significantly correlate with OSA, OFC, sex, age, or tonsillar position.
  • Mean cortical thickness in the cohort was 2.78mm.

Conclusions:

  • Papilloedema and hydrocephalus are significant indicators of altered cerebral cortex thickness in syndromic craniosynostosis.
  • Findings support proactive management strategies focusing on early detection of these specific risk factors.
  • This research highlights the importance of monitoring for papilloedema and hydrocephalus to prevent potential neurological sequelae.
Abstract

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