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Updated: Dec 28, 2025

A High-Throughput Enzyme-Coupled Activity Assay to Probe Small Molecule Interaction with the dNTPase SAMHD1
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A High-Throughput Enzyme-Coupled Activity Assay to Probe Small Molecule Interaction with the dNTPase SAMHD1

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Viperin, through its radical-SAM activity, depletes cellular nucleotide pools and interferes with mitochondrial

Kourosh H Ebrahimi1, Duncan Howie2, Jack S Rowbotham1

  • 1Department Chemistry, University of Oxford, UK.

FEBS Letters
|February 16, 2020
PubMed

Keywords:
NTPsRSAD2antiviralchain terminationddhCTPmetabolismmitochondriaradical-SAMunifying viewviperin

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