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Related Experiment Video

Updated: Dec 28, 2025

Modeling an Enzyme Active Site using Molecular Visualization Freeware

Modeling an Enzyme Active Site using Molecular Visualization Freeware

Published on: December 25, 2021

MichelaNglo: sculpting protein views on web pages without coding.

Matteo P Ferla^1,2, Alistair T Pagnamenta¹, David Damerell²

¹NIHR Oxford BRC Genomic Medicine, Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.

Bioinformatics (Oxford, England)

|February 16, 2020

Summary

Michelaɴɢʟo is a new web tool that allows scientists to easily create and share interactive 3D macromolecular structures online, moving beyond static images. This application requires no programming skills, making 3D visualizations accessible to a wider audience.

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Last Updated: Dec 28, 2025

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Area of Science:

Structural Biology
Bioinformatics
Web Development

Background:

Sharing macromolecular structural data online typically relies on static 2D images.
Embedding interactive 3D structures in web pages is challenging and often requires advanced web coding expertise.

Purpose of the Study:

To develop an accessible, open-source web-based application for generating and sharing interactive 3D macromolecular visualizations.
To enable researchers to present complex protein structures in a more engaging and understandable format without programming knowledge.

Main Methods:

Utilizes the NGL JavaScript library for creating 3D visualizations.
Accepts PyMOL files, PDB files, PDB identifiers, or protein/gene names as input.
Supports adding hyperlinks to control the 3D view and highlighting protein-coding variants.

Main Results:

Michelaɴɢʟo facilitates the creation, customization, and sharing of interactive 3D macromolecular visualizations.
Visualizations can be embedded into existing websites.
The application empowers researchers to move beyond static images for better communication of protein structures.

Conclusions:

Michelaɴɢʟo lowers the barrier to entry for creating and sharing interactive 3D macromolecular visualizations.
It enhances scientific communication by enabling more dynamic and accessible presentations of structural data.