Chemotherapy-associated steatohepatitis.
Lucy Meunier1, Dominique Larrey2
1Service d'Hépato-gastroentérologie et Transplantation, France.
Certain chemotherapy drugs can cause liver damage, known as Chemotherapy-induced Acute Steatohepatitis (CASH). Identifying these risks helps manage patient factors and improve treatment monitoring for better outcomes.
Area of Science:
- Hepatology
- Oncology
- Toxicology
Background:
- Some anti-cancer drugs can cause liver damage, mimicking Non-Alcoholic Fatty Liver Disease (NAFLD).
- This drug-induced liver injury is termed Chemotherapy-induced Acute Steatohepatitis (CASH).
Purpose of the Study:
- To highlight the risk of CASH from specific chemotherapies.
- To emphasize the importance of identifying and managing risk factors for CASH.
- To suggest treatment strategies in specific cancer contexts.
Main Methods:
- Review of existing literature on drug-induced liver injury.
- Analysis of the mechanisms of CASH, focusing on mitochondrial toxicity.
- Consideration of patient, disease, and treatment factors influencing CASH.
Main Results:
- Chemotherapy-induced Acute Steatohepatitis (CASH) is linked to mitochondrial toxicity.
- Patient, disease, and treatment variables significantly impact CASH development.
- Lesions are typically chronic but reversible upon treatment cessation.
Conclusions:
- Identifying chemotherapies causing steatosis/steatohepatitis is crucial for risk management.
- Enhanced monitoring and metabolic risk factor control are vital during chemotherapy.
- Optimizing neoadjuvant chemotherapy duration and timing relative to surgery may reduce complications in colorectal cancer patients.
More Related Videos
09:02Percutaneous Hepatic Perfusion PHP with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver
Published on: July 31, 2016
06:38An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis
Published on: September 12, 2019
Related Concept Videos
02:49Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
01:28Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists
01:27Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists
01:22Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test
01:29Chronic Pancreatitis II: Collaborative Care
Assessment:
02:50Combination Therapies and Personalized Medicine
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...