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Switch of tablet manufacturing from high shear granulation to twin-screw granulation using quality by design approach

Yuta Miyazaki1, Vincent Lenhart2, Peter Kleinebudde2

  • 1Heinrich Heine University, Institute of Pharmaceutics and Biopharmaceutics, Universitaetsstr. 1, 40225 Duesseldorf, Germany; ONO Pharmaceutical Co., Ltd., CMC & Production HQs, Pharmaceutical Product Development & Management, Pharmaceutical Product Development, Non-Sterile Product, 15-26 Kamiji 1-Chome Higashinari-ku, 537-0003 Osaka, Japan.

International Journal of Pharmaceutics
|February 17, 2020
PubMed

Keywords:
Equivalent dissolution profileGranule strengthHigh shear granulationTwin-screw granulation

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