Related Experiment Video
Updated: Dec 28, 2025

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
Published on: April 23, 2019
Decrease in Urologic Discharge Opioid Prescribing after Mandatory Query of Statewide Prescription Drug Monitoring
John M Myrga1, Liam C Macleod2, Jathin Bandari1
1University of Pittsburgh School of Medicine, Department of Urology, Pittsburgh, PA.
The Pennsylvania Prescription Drug Monitoring Program (PDMP) query mandate reduced postoperative opioid prescribing by 18% in major urologic surgery patients. This finding suggests PDMP mandates can curb opioid overprescribing in surgical settings.
Area of Science:
- Urology
- Pharmacology
- Public Health
Background:
- Opioid overprescribing is a major public health concern.
- Prescription Drug Monitoring Programs (PDMPs) aim to reduce opioid misuse.
- The impact of PDMP mandates on postoperative opioid prescribing remains unclear.
Purpose of the Study:
- To evaluate the effectiveness of the Pennsylvania PDMP mandate on discharge opioid prescriptions.
- To assess changes in opioid prescribing for patients undergoing major urologic procedures.
Main Methods:
- Retrospective analysis of 582 patients undergoing major prostate or renal surgery.
- Comparison of opioid prescribing trends before and after the PDMP query mandate.
- Measurement of 5mg oxycodone equivalents for opioid-naive and opioid-tolerant patients.
Main Results:
- No significant change in the number of opioid prescriptions issued.
- An 18% decrease in the median number of 5mg oxycodone equivalents prescribed post-mandate (P < .001).
- Consistent reduction observed in both opioid-naive and opioid-exposed populations.
Conclusions:
- Mandatory PDMP queries may reduce the quantity of discharge opioid prescriptions in surgical settings.
- This study is the first to demonstrate PDMP effectiveness in reducing postoperative opioid prescribing.
- PDMP mandates show potential for mitigating harms associated with opioid overprescribing.
More Related Videos
16:02Demonstration of the Sequence Alignment to Predict Across Species Susceptibility Tool for Rapid Assessment of Protein Conservation
Published on: February 10, 2023
10:13Author Spotlight: An Efficient Methodology to Confidently Differentiate and Characterize Fentanyl Analogs
Published on: November 8, 2024
Related Concept Videos
Prescription, Nonprescription and Orphan Drugs
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
Pharmacovigilance
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
Opioid Analgesics: Synthetic and Semisynthetic Opioids
Drugs Affecting GI Tract Motility: Opioids as Antidiarrheal Agents
Opioids, widely used antidiarrheal agents, mitigate diarrhea by slowing down...
Analgesia and Pain Management
Drug Abuse and Addiction: Pharmacological Phenomena