Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Protein-protein Interfaces02:04

Protein-protein Interfaces

14.4K
Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
14.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Fluticasone Propionate/Anti-IgE Combination Preserves Bone Mechanical and Mineral Integrity Better than Monotherapies or Anti-TNF-α in Mice with Ovalbumin-Induced Allergic Airway Inflammation.

International journal of molecular sciences·2026
Same author

Determination of the yearly distribution of the incidence of Allergic Bronchopulmonary Aspergillosis (ABPA) in patients registered in the cystic fibrosis patient registry system of Turkey and identification of risk factors for its development.

Chronic illness·2026
Same author

DeepAlloWeb: a web server for interactive allosteric pockets prediction using protein language model.

Journal of molecular biology·2026
Same author

The Evaluation of the Genotype and Phenotype Relationship in Patients With Nasal Polyps in Cystic Fibrosis Registry of Turkey.

Pediatric pulmonology·2026
Same author

Repurposing AI for protein interactions and dynamics: opportunities, limitations, and lessons.

Frontiers in bioinformatics·2026
Same author

Deep generative molecular design and its value in modern drug discovery.

Expert opinion on drug discovery·2026

Related Experiment Video

Updated: Dec 28, 2025

Biomimetic Materials to Characterize Bacteria-host Interactions
12:22

Biomimetic Materials to Characterize Bacteria-host Interactions

Published on: November 16, 2015

9.8K

HMI-PRED: A Web Server for Structural Prediction of Host-Microbe Interactions Based on Interface Mimicry.

Emine Guven-Maiorov1, Asma Hakouz2, Sukejna Valjevac2

  • 1Computational Structural Biology Section, Basic Science Program, Frederick National Laboratory for Cancer Research, Frederick, MD, 21702, USA.

Journal of Molecular Biology
|February 17, 2020
PubMed
Summary

Microbial proteins can hijack host cells by mimicking binding surfaces, altering host signaling and immune responses. The HMI-PRED web server predicts these host-microbe interactions (HMIs) to understand their role in health and disease.

Keywords:
HMIHPIcomputational predictionhost-microbe interactionhost-pathogen interactioninterface mimicrymodelingprotein-protein interactionstructure

More Related Videos

A Comparative Approach to Characterize the Landscape of Host-Pathogen Protein-Protein Interactions
13:56

A Comparative Approach to Characterize the Landscape of Host-Pathogen Protein-Protein Interactions

Published on: July 18, 2013

11.5K
Author Spotlight: Advanced Enteroid Model for Studying Host-Pathogen Interactions
07:56

Author Spotlight: Advanced Enteroid Model for Studying Host-Pathogen Interactions

Published on: April 5, 2024

2.4K

Related Experiment Videos

Last Updated: Dec 28, 2025

Biomimetic Materials to Characterize Bacteria-host Interactions
12:22

Biomimetic Materials to Characterize Bacteria-host Interactions

Published on: November 16, 2015

9.8K
A Comparative Approach to Characterize the Landscape of Host-Pathogen Protein-Protein Interactions
13:56

A Comparative Approach to Characterize the Landscape of Host-Pathogen Protein-Protein Interactions

Published on: July 18, 2013

11.5K
Author Spotlight: Advanced Enteroid Model for Studying Host-Pathogen Interactions
07:56

Author Spotlight: Advanced Enteroid Model for Studying Host-Pathogen Interactions

Published on: April 5, 2024

2.4K

Area of Science:

  • Microbiology
  • Structural Biology
  • Bioinformatics

Background:

  • Microbes interact with host cells, influencing functions and immune responses.
  • Understanding microbial protein interactions with host proteins is crucial for discerning their role in health and disease.
  • Microbial proteins can rewire host signaling pathways through protein-protein interactions (PPIs).

Purpose of the Study:

  • To develop a user-friendly web server for predicting structural protein-protein interactions (PPIs) between host and microbial species.
  • To identify how microbial proteins hijack host binding surfaces via "interface mimicry".
  • To facilitate large-scale, efficient identification of host-microbe interactions (HMIs).

Main Methods:

  • HMI-PRED utilizes structural prediction of PPIs between host and microbial proteins.
  • The server employs the "interface mimicry" principle for predicting interactions.
  • Users can input microbial protein structures or homology models to predict HMIs.

Main Results:

  • HMI-PRED provides structural models of potential host-microbe interaction (HMI) complexes.
  • It lists host endogenous and exogenous PPIs that can be disrupted by microbial proteins.
  • The server also predicts the tissue expression of microbe-targeted host proteins.

Conclusions:

  • HMI-PRED is a valuable tool for predicting structural host-microbe interactions.
  • The server aids in understanding how microbial proteins affect host signaling and PPIs.
  • Prediction results are stored in a repository for community access, promoting research on HMIs.