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Related Experiment Video

Updated: Dec 28, 2025

Probiotic Studies in Neonatal Mice Using Gavage

Probiotic Studies in Neonatal Mice Using Gavage

Published on: January 27, 2019

Gut microbiota composition during infancy and subsequent behavioural outcomes.

Amy Loughman¹, Anne-Louise Ponsonby², Martin O'Hely³

¹Deakin University, Geelong, Victoria 3220, Australia.

|February 17, 2020

Summary

A study found that lower levels of Prevotella bacteria in infants at 12 months were linked to more behavioral problems at two years. This highlights the gut microbiome

Keywords:

Behaviour Gut-brain axis Infant Microbiota

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Last Updated: Dec 28, 2025

Probiotic Studies in Neonatal Mice Using Gavage

Probiotic Studies in Neonatal Mice Using Gavage

Published on: January 27, 2019

Intracerebroventricular Delivery of Gut-Derived Microbial Metabolites in Freely Moving Mice

Intracerebroventricular Delivery of Gut-Derived Microbial Metabolites in Freely Moving Mice

Published on: June 2, 2022

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

Area of Science:

Microbiome research
Developmental psychology
Pediatric health

Background:

Longitudinal human data on the gut microbiota-brain axis is limited.
Understanding infant gut microbiome composition is crucial for development.

Purpose of the Study:

To investigate the relationship between infant gut microbiota composition and later behavioral outcomes.
To identify specific microbial patterns associated with behavioral development.

Main Methods:

Analysis of fecal microbiota from 201 children at 1, 6, and 12 months.
Behavioral outcomes assessed at 2 years of age within a longitudinal Australian birth cohort.
Statistical analysis controlling for confounding variables.

Main Results:

A significant association was found between lower Prevotella abundance at 12 months and increased behavioral problems at 2 years.
Internalizing Problem scores were particularly associated with reduced Prevotella.
Antibiotic exposure was the strongest predictor of decreased Prevotella abundance.

Conclusions:

Infant gut microbiota composition is strongly linked to subsequent behavioral outcomes.
Findings underscore the importance of responsible antibiotic use in early life for neurodevelopment.
This research provides critical longitudinal evidence for the gut-brain connection in infancy.