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RNA-based pharmacotherapy for tumors: From bench to clinic and back

Xiangping Liang1, Dongpei Li2, Shuilong Leng3

  • 1Guangdong Key Laboratory for Research and Development of Natural Drugs, Guangdong Medical University, Zhanjiang, China; Southern Marine Science and Engineering Guangdong Laboratory Zhanjiang, The Marine Medical Research Institute of Guangdong Zhanjiang (GDZJMMRI), Guangdong Medical University, Zhanjiang, China.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|February 17, 2020
PubMed

Insights

RNA therapy offers a novel approach to treating diseases by regulating messenger RNA (mRNA) metabolism. This review explores RNA therapy

Area of Science:

  • Biotechnology
  • Molecular Biology
  • Genetics

Background:

  • RNA therapy targets messenger RNA (mRNA) metabolism for disease treatment.
  • It shows promise for incurable conditions like hereditary diseases and tumors.
  • This field has seen significant advancements in recent years.

Purpose of the Study:

  • To review the discovery and development of RNA therapy.
  • To discuss its classification, mechanisms, advantages, and challenges.
  • To highlight its application in oncology and clinical trials.

Main Methods:

  • Literature review of RNA therapy research.
  • Analysis of RNA therapy mechanisms, particularly in tumor cell targeting.
  • Examination of RNA-based anti-tumor drug development and clinical trials.

Main Results:

  • RNA therapy involves regulating cell proteins via mRNA metabolism.
  • It has demonstrated potential in treating hereditary diseases and cancers.
  • Progress in RNA anti-tumor drug development and clinical trials is significant.

Conclusions:

  • RNA therapy is a rapidly advancing field with broad therapeutic potential.
  • Its application in oncology is a key area of ongoing research.
  • Further development and clinical trials are crucial for realizing its full impact.
Keywords:
Cancer immunotherapyClinical trialsRNA drugsRNA therapy

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