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Local Anesthetics: Adverse Effects

Local Anesthetics: Adverse Effects

While local anesthetics are generally safe and well-tolerated, they can occasionally cause adverse effects that vary in severity. Local anesthetics can induce toxicity at two distinct levels. They can either produce local effects through direct contact with the neural elements or be absorbed into the bloodstream from the injection site, leading to systemic effects.
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...

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Updated: Dec 28, 2025

2-Vessel Occlusion/Hypotension: A Rat Model of Global Brain Ischemia

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Published on: June 22, 2013

Fentanyl Overdose Causing Hippocampal Ischaemia Followed by Delayed Leukoencephalopathy

Aaron R Switzer¹, Benjamin Beland¹, Justyna R Sarna^1,2

¹Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.

The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques

|February 18, 2020

Summary

No abstract available in PubMed .

Keywords:

Cognitive Impairment Fentanyl Overdose Ischemic Brain Injury Magnetic Resonance Imaging Toxic Leukoencephalopathy

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