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[Mechanism of hematuria in hematuric nephritis]
Peripheral blood erythrocytic functional disorders were studied in 31 patients with primary and secondary hematuric nephritides. A decrease in erythrocyte normal charge was noted in 90%, erythrocyte fragmentation in 43%. Reverse correlation was established between a degree of lowered peripheral blood erythrocyte charge and serum IgA concentration (R = -0.65 +/- 0.15). The role of the detected erythrocytic disorders in the mechanisms of hematuria, the involvement of local (renal) intravascular coagulation in the pathogenesis of hematuric nephritides were discussed.
Peripheral blood erythrocytic functional disorders were studied in 31 patients with primary and secondary hematuric nephritides. A decrease in erythrocyte normal charge was noted in 90%, erythrocyte fragmentation in 43%. Reverse correlation was established between a degree of lowered peripheral blood erythrocyte charge and serum IgA concentration (R = -0.65 +/- 0.15). The role of the detected erythrocytic disorders in the mechanisms of hematuria, the involvement of local (renal) intravascular coagulation in the pathogenesis of hematuric nephritides were discussed.